Nek2 kinase in chromosome instability and cancer

被引：142

作者：

Hayward, Daniel G. ^{[1
]}

Fry, Andrew M. ^{[1
]}

机构：

[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

来源：

CANCER LETTERS | 2006年 / 237卷 / 02期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Nek2A; Nek2B; centrosome; mitosis; aneuploidy;

D O I：

10.1016/j.canlet.2005.06.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aneuploidy and chromosome instability are two of the most common abnormalities in cancer cells. They arise through defects in cell division and, specifically, in the unequal segregation of chromosomes between daughter cells during mitosis. A number of cell cycle dependent protein kinases have been identified that control mitotic progression and chromosome segregation. Some of these localize to the centrosome and regulate mitotic spindle formation. One such protein is Nek2, a member of the NIMA-related serine/threonine kinase family. Data are emerging that Nek2 is abnormally expressed in a wide variety of human cancers. In this review, we summarize current knowledge on the expression, regulation and function of Nek2, consider how Nek2 may contribute to chromosome instability, and ask whether it might make an attractive target for chemotherapeutic intervention in human cancer. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：155 / 166

页数：12

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