Increased risk of tuberculosis in patients with end-stage renal disease: a population-based cohort study in Taiwan, a country of high incidence of end-stage renal disease

被引：23

作者：

Hu, H. Y. ^{[1
,2
]}

Wu, C. Y. ^{[1
]}

Huang, N. ^{[2
,3
]}

Chou, Y. J. ^{[1
]}

Chang, Y. C. ^{[4
]}

Chu, D. ^{[1
,5
]}

机构：

[1] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 103, Taiwan

[2] Natl Yang Ming Univ, Dept Publ Hlth, Taipei 103, Taiwan

[3] Taipei City Hosp, Heping Fuyou Branch, Inst Hosp & Hlth, Taipei, Taiwan

[4] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan

[5] Taipei City Hosp, Dept Neurosurg, Taipei, Taiwan

来源：

EPIDEMIOLOGY AND INFECTION | 2014年 / 142卷 / 01期

关键词：

Cohort study; end-stage renal disease; Taiwan; tuberculosis; DIALYSIS PATIENTS; HEMODIALYSIS;

D O I：

10.1017/S0950268813000551

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This nationwide population-based cohort study investigated the risk of tuberculosis (TB) in patients with end-stage renal disease (ESRD) and receiving dialysis. The evaluations included 4131 incident ESRD patients receiving dialysis and 16524 age- and gender-matched controls, recruited between 1998 and 2009. We used Cox proportional hazards regression analysis to measure the association between TB and ESRD. Compared to the controls, the ESRD cohort had a significantly higher risk of TB within 1 year [incident rate ratio (IRR) 413], and 1-2 years (IRR 212), of occurrence of ESRD. The Cox proportional hazards model revealed that ESRD [hazard ratio (HR) 240], age >65 years (HR 241), male sex (HR 194), diabetes mellitus (HR 136), silicosis (HR 770) and chronic obstructive pulmonary disease (HR 161) are independent risk factors for TB. Patients with ESRD are associated with an increased risk of TB, and should thus be monitored more carefully for TB, especially within 2 years of onset of ESRD.

引用

页码：191 / 199

页数：9

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