HPLC Method for Simultaneous Analysis of Ranitidine and Metronidazole in Dosage Forms

被引：6
|
作者：
King'ori, Loti David [1 ]
Walker, Roderick B. [1 ]
机构：
[1] Rhodes Univ, Fac Pharm, Div Pharmaceut, ZA-6140 Grahamstown, South Africa
来源：
ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
Metronidazole; Ranitidine; HPLC; Stability-indicating; Validation; PROTON PUMP INHIBITORS; PERFORMANCE LIQUID-CHROMATOGRAPHY; HYDROCHLORIDE;
D O I：
10.14233/ajchem.2014.15432
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, rapid, precise and accurate, stability indicating HPLC method for the simultaneous analysis of metronidazole(and ranitidine in, forms has been developed and validated. Calibration curves for metronidazole and ranitidine exhibited linearity (R-2 = 0,9995 for both compounds) over the concenteration ranges investigated. The method was sensitive,selective and accurate for both compounds: Both I drugs Were found to be stable following; acid hydrolysis studies, However, following alkali hydrolysis degradation of both compounds I was observed. Furthermore metronidazole appeared to be Stable following, oxidative studies however ranitidine underwent complete degradation tinder these conditions. Both drugs were well resolved from the degradation product's. The stability indicating chromatographic ill method has the necessary precision and accuracy for the simultaneous analysis of metronidazole and ranitidine in dosage forms.
引用
收藏
页码：426 / 430
页数：5
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