On the Use of Amperometry for Real Time Assessment of Drug-Release Profile from Therapeutic Nanoparticles

被引：4

作者：

Ensafi, Ali A. ^{[1
]}

Heydari-Bafrooei, Esmaeil ^{[1
]}

Rezaei, Behzad ^{[1
]}

机构：

[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran

来源：

ELECTROANALYSIS | 2014年 / 26卷 / 04期

基金：

美国国家科学基金会;

关键词：

Drug release; Voltammetry; Doxorubicin; Liposome; Nanoparticles; PEGYLATED LIPOSOMAL DOXORUBICIN; TARGETED DELIVERY; IN-VITRO; VINCRISTINE; ELECTRODE; SYSTEMS; DNA; ANTHRACYCLINES; MICROSPHERES; PARACETAMOL;

D O I：

10.1002/elan.201300591

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple electrochemical method was used to directly assess the drug-release profile. The method is based on the multiple pulse amperometric measurement of the oxidation and reduction of doxorubicin released from liposome at a MWCNTs-modified glassy carbon electrode (MWCNT-GCE). The released doxorubicin was detected at +0.60 and -0.60V by two different oxidation and reduction processes, respectively. The third potential pulse (-1.00V) was applied for the regeneration of MWCNT-GCE. The main advantage of this method is that there is no need for any operation for the quantitative analysis during the release of the drug from nanoparticles.

引用

页码：776 / 785

页数：10

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