Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds

被引:35
作者
Ditta, Lorena Anna [1 ]
Rao, Estella [1 ]
Provenzano, Fiorenza [1 ]
Lozano Sanchez, Jesus [2 ,3 ]
Santonocito, Radha [1 ]
Passantino, Rosa [1 ]
Costa, Maria Assunta [1 ]
Sabatino, Maria Antonietta [4 ]
Dispenza, Clelia [1 ,4 ]
Giacomazza, Daniela [1 ]
San Biagio, Pier Luigi [1 ]
Lapasin, Romano [5 ]
机构
[1] CNR, Ist Biofis, Via U La Malfa 153, I-90146 Palermo, Italy
[2] Univ Granada, Dept Food Sci & Nutr, Campus Univ S-N, Granada 18071, Spain
[3] Ctr Res & Dev Funct Food, Hlth Sci Technol Pk,Avda Conocimiento S-N, Granada 18100, Spain
[4] Univ Palermo, Dipartimento Ingn, Viale Sci,Edifido 6, I-90128 Palermo, Italy
[5] Univ Trieste, Dipartimento Ingn & Architettura, Piazzale Europa, I-34127 Trieste, Italy
关键词
Agarose/kappa-carrageenan lend; Cryphaea heteromalla bryophyte; Wound healing; DRUG-DELIVERY SYSTEMS; CAFFEIC ACID; IN-VITRO; RELEASE; MECHANISMS; DRESSINGS; GELATION; JASMONATE; ALGINATE;
D O I
10.1016/j.ijbiomac.2020.08.170
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hydrogels for complex and chronic wound dressings must be conformable, absorb and retain wound exudates and maintain hydration. They can incorporate and release bioactive molecules that can accelerate the healing process. Wound dressings have to be in contact with the wound and epidermis, even for long periods, without causing adverse effects. Hydrogel dressing formulations based on biopolymers derived from terrestrial or marine flora can be relatively inexpensive and well tolerated. In the present article hydrogel films composed by agarose (1.0wt%),kappa-carrageenan at three different concentrations (0.5, 1.0 and 1.5wt%) and glycerol (3.0wt%) were prepared without recourse to crosslinking agents, and characterized for their mechanical properties, morphology, swelling and erosion behavior. The films resulted highly elastic and able to absorb and retain large amounts of fluids without losing their integrity. One of the films was loaded with the aqueous extract from Cryphaea heteromalla (Hedw.) D. Mohr for its antioxidant properties. Absence of cytotoxicity and ability to reduce the oxidative stress were demonstrated on NIH-3T3 fibroblast cell cultures. These results encourage further biological evaluations to assess their impact on the healing process. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码:2818 / 2830
页数:13
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