African Swine Fever Virus Gets Undressed: New Insights on the Entry Pathway

被引：48

作者：

Andres, German ^{[1
,2
]}

机构：

[1] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

[2] Univ Autonoma Madrid, Madrid, Spain

来源：

JOURNAL OF VIROLOGY | 2017年 / 91卷 / 04期

关键词：

African swine fever virus; virus entry; virus membrane fusion; virus uncoating; CELLS;

D O I：

10.1128/JVI.01906-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

African swine fever virus (ASFV) is a large, multienveloped DNA virus composed of a genome-containing core successively wrapped by an inner lipid envelope, an icosahedral protein capsid, and an outer lipid envelope. In keeping with this structural complexity, recent studies have revealed an intricate entry program. This Gem highlights how ASFV uses two alternative pathways, macropinocytosis and clathrin-mediated endocytosis, to enter into the host macrophage and how the endocytosed particles undergo a stepwise, low pH-driven disassembly leading to inner envelope fusion and core delivery in the cytoplasm.

引用

页数：5

共 21 条

[1] THE ENTRY OF AFRICAN SWINE FEVER VIRUS INTO VERO CELLS [J].

ALCAMI, A ;

CARRASCOSA, AL ;

VINUELA, E .

VIROLOGY, 1989, 171 (01) :68-75

[2] African swine fever virus proteinase is essential for core maturation and infectivity [J].

Alejo, A ;

Andrés, G ;

Salas, ML .

JOURNAL OF VIROLOGY, 2003, 77 (10) :5571-5577

[3] Repression of African swine fever virus polyprotein pp220-encoding gene leads to the assembly of icosahedral core-less particles [J].

Andrés, G ;

García-Escudero, R ;

Salas, ML ;

Rodríguez, JM .

JOURNAL OF VIROLOGY, 2002, 76 (06) :2654-2666

[4] Endosomal Maturation, Rab7 GTPase and Phosphoinositides in African Swine Fever Virus Entry [J].

Cuesta-Geijo, Miguel A. ;

Galindo, Inmaculada ;

Hernaez, Bruno ;

Ignacio Quetglas, Jose ;

Dalmau-Mena, Inmaculada ;

Alonso, Covadonga .

PLOS ONE, 2012, 7 (11)

[5] Vesicular Stomatitis Virus Enters Cells through Vesicles Incompletely Coated with Clathrin That Depend upon Actin for Internalization [J].

Cureton, David K. ;

Massol, Ramiro H. ;

Saffarian, Saveez ;

Kirchhausen, Tomas L. ;

Whelan, Sean P. J. .

PLOS PATHOGENS, 2009, 5 (04)

[6] VIRAL-RNA MODULATES THE ACID SENSITIVITY OF FOOT-AND-MOUTH-DISEASE VIRUS CAPSIDS [J].

CURRY, S ;

ABRAMS, CC ;

FRY, E ;

CROWTHER, JC ;

BELSHAM, GJ ;

STUART, DI ;

KING, AMQ .

JOURNAL OF VIROLOGY, 1995, 69 (01) :430-438

[7] African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis [J].

Galindo, Inmaculada ;

Angel Cuesta-Geijo, Miguel ;

Hlavova, Karolina ;

Munoz-Moreno, Raquel ;

Barrado-Gil, Lucia ;

Dominguez, Javier ;

Alonso, Covadonga .

VIRUS RESEARCH, 2015, 200 :45-55

[8] African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes [J].

Hernaez, Bruno ;

Guerra, Milagros ;

Salas, Maria L. ;

Andres, German .

PLOS PATHOGENS, 2016, 12 (04)

[9] Dynamin- and Clathrin-Dependent Endocytosis in African Swine Fever Virus Entry [J].

Hernaez, Bruno ;

Alonso, Covadonga .

JOURNAL OF VIROLOGY, 2010, 84 (04) :2100-2109

[10] Evolutionary genomics of nucleo-cytoplasmic large DNA viruses [J].

Iyer, LA ;

Balaji, S ;

Koonin, EV ;

Aravind, L .

VIRUS RESEARCH, 2006, 117 (01) :156-184

← 1 2 3 →