Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells

被引：167

作者：

Palozza, Paola ^{[1
]}

Torelli, Cristiana ^{[1
]}

Boninsegna, Alma ^{[1
]}

Simone, Rossella ^{[1
]}

Catalano, Assunta ^{[1
]}

Mele, Maria Cristina ^{[2
]}

Picci, Nevio ^{[3
]}

机构：

[1] Catholic Univ, Inst Gen Pathol, Sch Med, I-00168 Rome, Italy

[2] Catholic Univ, Inst Biochem & Clin Biochem, Sch Med, I-00168 Rome, Italy

[3] Univ Calabria, Dept Pharmaceut Sci, I-87036 Cosenza, Italy

来源：

CANCER LETTERS | 2009年 / 283卷 / 01期

关键词：

Haematococcus pluvialis; Astaxanthin; Cell cycle; Apoptosis; Cell survival; Human colon cancer cells; DIETARY BETA-CAROTENE; NATURALLY-OCCURRING XANTHOPHYLLS; LUNG-CANCER; CYCLE PROGRESSION; DOWN-REGULATION; ANTIOXIDANT ACTIVITY; NEUROBLASTOMA-CELLS; INDUCED APOPTOSIS; TOBACCO-SMOKE; TUMOR-CELLS;

D O I：

10.1016/j.canlet.2009.03.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The growth-inhibitory effects of the astaxanthin-rich Haematococcus pluvialis were studied in HCT-116 colon cancer cells. H. pluvialis extract (5-25 mu g/ml) inhibited cell growth in a dose- and time-dependent manner, by arresting cell cycle progression and by promoting apoptosis. At 25 mu g/ml of H. pluvialis extract, an increase of p53, p21(WAF-1/CIP-1) and p27 expression (220%, 160%, 250%, respectively) was observed, concomitantly with a decrease of cyclin D1 expression (58%) and AKT phosphorylation (21%). Moreover, the extract, at the same concentration, strongly up-regulated apoptosis by modifying the ratio of Bax/Bcl-2 and Bcl-XL, and increased the phosphorylation of p38, JNK, and ERK1/2 by 160%, 242%. 280%, respectively. Growth-inhibitory effects by H. pluvialis were also observed in HT-29. LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：108 / 117

页数：10

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