KF-alumina-mediated selective double Michael additions of aryl methyl ketones: A facile entry to the synthesis of functionalized pimelate esters and derivatives

被引：13

作者：

Basu, B ^{[1
]}

Das, P ^{[1
]}

Hossain, I ^{[1
]}

机构：

[1] N Bengal Univ, Dept Chem, Darjeeling 734430, India

来源：

SYNLETT | 2004年 / 12期

关键词：

double Michael additions; acetophenone; KF-alumina; pimelate esters; cyclohexanones;

D O I：

10.1055/s-2004-831339

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we describe simple and efficient double Michael additions of aromatic and aliphatic methyl ketones to electron deficient alkenes promoted on a surface of KF-alumina. This one-pot procedure provides an easy access to a host of functionalized pimelate esters, which can be subsequently converted in to 3-acylcyclohexanones.

引用

页码：2224 / 2226

页数：3