Hepcidin/Ferritin Ratios Differ Among Non-Dialyzed Chronic Kidney Disease Patients, and Patients on Hemodialysis and Peritoneal Dialysis

被引：7

作者：

Niikura, Takahito ^{[1
,2
]}

Maruyama, Yukio ^{[1
]}

Nakashima, Satomi ^{[1
]}

Matsuo, Nanae ^{[1
]}

Tanno, Yudo ^{[1
]}

Ohkido, Ichiro ^{[1
]}

Yokoyama, Keitaro ^{[1
]}

Yamamoto, Hiroyasu ^{[1
]}

Yokoo, Takashi ^{[1
]}

机构：

[1] Jikei Univ, Div Nephrol & Hypertens, Sch Med, Tokyo, Japan

[2] Atsugi City Hosp, Dept Internal Med, Atsugi, Kanagawa, Japan

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2019年 / 23卷 / 04期

关键词：

Chronic kidney disease; Hemodialysis; Hepcidin; ferritin ratio; Hepcidin-25; Peritoneal dialysis; SERUM HEPCIDIN-25 LEVELS; IRON; ANEMIA; INFLAMMATION; FERROPORTIN; OUTCOMES;

D O I：

10.1111/1744-9987.12773

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The serum levels of hepcidin generally increase in patients with chronic kidney disease (CKD) due to inflammation or a decline in the glomerular filtration rate. However, the differences in the ferrokinetics among dialysis modalities are unclear. We investigated the relationship between serum levels of hepcidin and ferritin among non-dialyzed CKD (ND), hemodialysis (HD), and peritoneal dialysis (PD) patients. We recruited 285 CKD patients (117 ND, 80 HD, and 88 PD patients) and measured the serum levels of hepcidin-25, ferritin, hemoglobin, iron, transferrin saturation (TSAT), albumin, and high sensitivity C-reactive protein (hs-CRP). Hepcidin-25 levels were elevated in all CKD patients and were significantly higher in PD than in ND and HD patients. The hepcidin/ferritin ratio was significantly higher in PD patients independent of TSAT, hemoglobin, hs-CRP, and serum albumin. Hepcidin/ferritin ratio, associated with both dialysis modality and inflammation, is expected to be a useful indicator of anemia in CKD.

引用

页码：341 / 346

页数：6

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