Multiple sclerosis and neurofibromatosis type 1: report of seven patients from Iran

被引：15

作者：

Etemadifar, M. ^{[1
,2
,3
]}

Fatehi, F. ^{[1
,2
,3
,4
]}

Sahraian, M. A. ^{[5
,6
]}

Borhani-Haghighi, A. ^{[7
]}

Ardestani, P. M. ^{[8
]}

Kaji-Esfahani, M. ^{[9
]}

Maghzi, A. H. ^{[2
,3
,10
]}

机构：

[1] Isfahan Univ Med Sci, Dept Neurol, Esfahan, Iran

[2] Isfahan Univ Med Sci, Isfahan Neurosci Res Ctr, Esfahan, Iran

[3] Isfahan Univ Med Sci, Al Zahra Hosp, IRCOMS, Esfahan, Iran

[4] Isfahan Univ Med Sci, Isfahan Med Educ Res Ctr, Esfahan, Iran

[5] Univ Tehran Med Sci, Sina Hosp, Sina MS Res Ctr, Tehran, Iran

[6] Univ Tehran Med Sci, Dept Neurol, Tehran, Iran

[7] Shiraz Univ Med Sci, Nemazee Hosp, Dept Neurol, Shiraz, Iran

[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Neurosci Lab 2, Dept Anat, Singapore 117548, Singapore

[9] Islamic Azad Univ Najafabad, Dept Radiol, Esfahan, Iran

[10] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, Ctr Neurosci, Neuroimmunol Unit, London, England

来源：

MULTIPLE SCLEROSIS JOURNAL | 2009年 / 15卷 / 09期

关键词：

autoimmune; Iran; multiple sclerosis; neurofibromatosis; GENE; MRI; SUPPRESSOR; NF1;

D O I：

10.1177/1352458509106612

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Co-occurrence of multiple sclerosis (MS) and neurofibromatosis type 1 (NF1) is rare. Case reports In this study, we describe the clinical and neuroimaging features of seven patients with NF1 and MS. In our patients, six patients with MS were women, in all of them history of NF1 existed. Three of our patients had primary progressive, one had secondary progressive MS, and three relapsing-remitting MS. Optic neuritis as presenting symptoms was seen in three patients, and motor manifestation as presenting symptom was observed in three patients. The risk of having both NF1 and MS seemed to be higher than would be expected based on the prevalence rates of the two diseases in the general population. Conclusion The findings of this study suggest a possible casual relationship between MS and NF1, indicating higher risk of MS among patients with NF1. Multiple Sclerosis 2009; 15: 1126-1130. http://msj.sagepub.com

引用

页码：1126 / 1130

页数：5

共 20 条

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