Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury

被引：7

作者：

P. Drasites, Kelsey ^{[1
,2
,3
]}

Shams, Ramsha ^{[1
,2
,3
]}

Zaman, Vandana ^{[1
,4
]}

Matzelle, Denise ^{[1
,4
]}

C. Shields, Donald ^{[1
]}

P. Garner, Dena ^{[3
]}

J. Sole, Christopher ^{[3
]}

Haque, Azizul ^{[2
]}

Banik, Narendra L. ^{[1
,2
,4
]}

机构：

[1] Med Univ South Carolina, Dept Neurosurg, 96 Jonathan Lucas St, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Dept Microbiol & Immunol, 173 Ashley Ave, Charleston, SC 29425 USA

[3] Citadel, Dept Hlth & Human Performance, 171 Moultrie St, Charleston, SC 29409 USA

[4] Ralph H Johnson Vet Adm Med Ctr, 109 Bee St, Charleston, SC 29401 USA

来源：

BRAIN SCIENCES | 2020年 / 10卷 / 12期

关键词：

muscle atrophy; calpain; inflammation; estrogen; biomarkers; neuroprotection; CLINICAL-PRACTICE; CALPAIN-I; ESTROGEN; ATROPHY; NEURONS; REGENERATION; REPLACEMENT; ACTIVATION; MECHANISMS; APOPTOSIS;

D O I：

10.3390/brainsci10120933

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A spinal cord injury (SCI) may lead to loss of strength, sensation, locomotion and other body functions distal to the lesion site. Individuals with SCI also develop secondary conditions due to the lack of skeletal muscle activity. As SCI case numbers increase, recent studies have attempted to determine the best options to salvage affected musculature before it is lost. These approaches include pharmacotherapeutic options, immunosuppressants, physical activity or a combination thereof. Associated biomarkers are increasingly used to determine if these treatments aid in the protection and reconstruction of affected musculature.

引用

页码：1 / 13

页数：13

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