Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury

被引：7

作者：

P. Drasites, Kelsey ^{[1
,2
,3
]}

Shams, Ramsha ^{[1
,2
,3
]}

Zaman, Vandana ^{[1
,4
]}

Matzelle, Denise ^{[1
,4
]}

C. Shields, Donald ^{[1
]}

P. Garner, Dena ^{[3
]}

J. Sole, Christopher ^{[3
]}

Haque, Azizul ^{[2
]}

Banik, Narendra L. ^{[1
,2
,4
]}

机构：

[1] Med Univ South Carolina, Dept Neurosurg, 96 Jonathan Lucas St, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Dept Microbiol & Immunol, 173 Ashley Ave, Charleston, SC 29425 USA

[3] Citadel, Dept Hlth & Human Performance, 171 Moultrie St, Charleston, SC 29409 USA

[4] Ralph H Johnson Vet Adm Med Ctr, 109 Bee St, Charleston, SC 29401 USA

来源：

BRAIN SCIENCES | 2020年 / 10卷 / 12期

关键词：

muscle atrophy; calpain; inflammation; estrogen; biomarkers; neuroprotection; CLINICAL-PRACTICE; CALPAIN-I; ESTROGEN; ATROPHY; NEURONS; REGENERATION; REPLACEMENT; ACTIVATION; MECHANISMS; APOPTOSIS;

D O I：

10.3390/brainsci10120933

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A spinal cord injury (SCI) may lead to loss of strength, sensation, locomotion and other body functions distal to the lesion site. Individuals with SCI also develop secondary conditions due to the lack of skeletal muscle activity. As SCI case numbers increase, recent studies have attempted to determine the best options to salvage affected musculature before it is lost. These approaches include pharmacotherapeutic options, immunosuppressants, physical activity or a combination thereof. Associated biomarkers are increasingly used to determine if these treatments aid in the protection and reconstruction of affected musculature.

引用

页码：1 / 13

页数：13

共 50 条

[21] Spasticity and preservation of skeletal muscle mass in people with spinal cord injury
Cha, Seungwoo
Yun, Jae-Hyun
Myong, Youho
Shin, Hyung-Ik
SPINAL CORD, 2019, 57 (04) : 317 - 323
[22] Does being female provide a neuroprotective advantage following spinal cord injury?
Jeffrey P.Datto
Jackie Yang
W.Dalton Dietrich
Damien D.Pearse
NeuralRegenerationResearch, 2015, 10 (10) : 1533 - 1536
[23] Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches
Gu, Guangjin
Yu, Huaqi
Zou, Huishuang
Kou, Wenjuan
Zhang, Pingping
Gu, Guangjie
Lu, Jie
Shi, Weihan
Chu, Pengcheng
Zhang, Yaning
Sun, Guangwei
Shang, Jun
FRONTIERS IN BIOSCIENCE-LANDMARK, 2024, 29 (06):
[24] Does being female provide a neuroprotective advantage following spinal cord injury?
Datto, Jeffrey P.
Yang, Jackie
Dietrich, W. Dalton
Pearse, Damien D.
Neural Regeneration Research, 2015, 10 (10) : 1533 - 1536
[25] Influence of complete spinal cord injury on skeletal muscle within 6 mo of injury
Castro, MJ
Apple, DF
Staron, RS
Campos, GER
Dudley, GA
JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (01) : 350 - 358
[26] Complement-dependent neuroinflammation in spinal cord injury: from pathology to therapeutic implications
Saad, Hassan
El Baba, Bachar
Tfaily, Ali
Kobeissy, Firas
Gonzalez, Juanmarco Gutierrez
Refai, Daniel
Rodts, Gerald R.
Mustroph, Christian
Gimbel, David
Grossberg, Jonathan
Barrow, Daniel L.
Gary, Matthew F.
Alawieh, Ali M.
NEURAL REGENERATION RESEARCH, 2025, 20 (05) : 1324 - 1335
[27] Mechanism of effect and therapeutic potential of NLRP3 inflammasome in spinal cord injury
Gu, Hou-yun
Liu, Ning
EXPERIMENTAL NEUROLOGY, 2025, 384
[28] Protective effects of gonadal hormones on spinal motoneurons following spinal cord injury
Sengelaub, Dale R.
Xu, Xiao-Ming
NEURAL REGENERATION RESEARCH, 2018, 13 (06) : 971 - 976
[29] Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
Samano, Cynthia
Mladinic, Miranda
Mazzone, Graciela L.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE, 2021, 15
[30] Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets
Yu, Mengsi
Wang, Zhiying
Wang, Dongmin
Aierxi, Milikemu
Ma, Zhanjun
Wang, Yonggang
JOURNAL OF NEUROSCIENCE RESEARCH, 2023, 101 (10) : 1538 - 1554

← 1 2 3 4 5 →