Hit and lead criteria in drug discovery for infectious diseases of the developing world

被引：466

作者：

Katsuno, Kei ^{[1
]}

Burrows, Jeremy N. ^{[2
]}

Duncan, Ken ^{[3
]}

van Huijsduijnen, Rob Hooft ^{[2
]}

Kaneko, Takushi ^{[4
]}

Kita, Kiyoshi ^{[5
]}

Mowbray, Charles E. ^{[6
]}

Schmatz, Dennis ^{[2
]}

Warner, Peter ^{[3
]}

Slingsby, B. T. ^{[1
]}

机构：

[1] Global Hlth Innovat Technol GHIT Fund, Minato Ku, Tokyo 1060032, Japan

[2] Med Malaria Venture, CH-1215 Geneva 15, Switzerland

[3] Bill & Melinda Gates Fdn, Seattle, WA 98102 USA

[4] Global Alliance TB Drug Dev, TB Alliance, New York, NY 10005 USA

[5] Univ Tokyo, Bunkyo Ku, Tokyo 1130033, Japan

[6] Drugs Neglected Dis Initiat, CH-1202 Geneva, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2015年 / 14卷 / 11期

关键词：

PLASMODIUM-FALCIPARUM; ARTEMISININ RESISTANCE; TUBERCULOSIS; MALARIA; MODEL; ASSAY; CHALLENGES; MECHANISM; IDENTIFY; INHIBITORS;

D O I：

10.1038/nrd4683

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Reducing the burden of infectious diseases that affect people in the developing world requires sustained collaborative drug discovery efforts. The quality of the chemical starting points for such projects is a key factor in improving the likelihood of clinical success, and so it is important to set clear go/no-go criteria for the progression of hit and lead compounds. With this in mind, the Japanese Global Health Innovative Technology (GHIT) Fund convened with experts from the Medicines for Malaria Venture, the Drugs for Neglected Diseases initiative and the TB Alliance, together with representatives from the Bill & Melinda Gates Foundation, to set disease-specific criteria for hits and leads for malaria, tuberculosis, visceral leishnnaniasis and Chagas disease. Here, we present the agreed criteria and discuss the underlying rationale.

引用

页码：751 / 758

页数：8

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