TGF-β: A New Role for an Old AktTOR

被引：9

作者：

Goraksha-Hicks, Pankuri ^{[1
,2
]}

Rathmell, Jeffrey C. ^{[1
,2
,3
]}

机构：

[1] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Duke Univ, Sarah W Stedman Ctr Nutr & Metab, Durham, NC 27710 USA

[3] Duke Univ, Dept Immunol, Durham, NC 27710 USA

来源：

DEVELOPMENTAL CELL | 2009年 / 17卷 / 01期

关键词：

CELL-SIZE;

D O I：

10.1016/j.devcel.2009.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nutrient overabundance is known to promote cellular hypertrophy, a significant pathological event in diseases like diabetes and cancer, although mechanisms have remained unclear. In this issue of Developmental Cell, Wu and Derynck provide a new model that links metabolism and cell growth by demonstrating that hyperglycemia can increase TGF-beta-dependent activation of the mTOR pathway to promote cellular hyperplasia.

引用

页码：6 / 8

页数：3

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