Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines

被引：6

作者：

Hua, Guoxiong ^{[1
]}

Du, Junyi ^{[1
]}

Slawin, Alexandra M. Z. ^{[1
]}

Woollins, J. Derek ^{[1
]}

机构：

[1] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

MOLECULES | 2017年 / 22卷 / 01期

关键词：

cyanamides; haloketones; selenazol-2-amines; selenoureas; Woollins' reagent; PRIMARY SELENOCARBOXYLIC AMIDES; AQUEOUS-PHASE SYNTHESIS; WOOLLINS REAGENT; PRIMARY SELENOAMIDES; FACILE PREPARATION; BETA-CYCLODEXTRIN; SELENIUM; NITRILES; 1,3-SELENAZOLE; HETEROCYCLES;

D O I：

10.3390/molecules22010046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of -haloketones. The selenoureas were obtained from the reaction of Woollins' reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (H-1, C-13, Se-77) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.

引用

页数：13

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