An updated research of glycogen synthase kinase-3β inhibitors: a review

被引：5
|
作者：
Liu, Shan-Kui [1 ]
Xie, Hong-Xu [1 ]
Ge, Yong-Xi [1 ]
Zhang, Juan [1 ]
Jiang, Cheng-Shi [1 ]
机构：
[1] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China
来源：
MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 01期
关键词：
GSK-3 beta inhibitor; Rational design; Multi-target; Selectivity; Structure-activity relationship; GSK-3; INHIBITORS; KINASE; 3-BETA; DISCOVERY; CURCUMIN; 1,2,3-TRIAZOLES; DERIVATIVES; DESIGN; POTENT;
D O I：
10.1007/s00706-020-02718-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Glycogen synthase kinase-3 beta (GSK-3 beta) is a highly conserved multifunctional serine/threonine (Ser/Thr) protein kinase widely expressed in many tissues. GSK-3 beta inhibitors could be used in the treatment of human key diseases, such as cancer, Alzheimer's disease, Parkinson's disease, inflammation, type-II diabetes, and so on, due to the multi-role of GSK-3 beta in the hepatic glycolysis regulation, cell signaling pathways, and phosphorylation of various proteins. Recently, sets of diverse GSK-3 beta inhibitors have been prepared, and biologically evaluated in vitro and in vivo in different screening models. This review summarizes the latest developments in GSK-3 beta inhibitors unclosed from 2015 to 2019, including their structure-activity relationship and bioactivity studies.
引用
收藏
页码：19 / 33
页数：15
相关论文
共 50 条
  • [1] An updated research of glycogen synthase kinase-3β inhibitors: a review
    Shan-Kui Liu
    Hong-Xu Xie
    Yong-Xi Ge
    Juan Zhang
    Cheng-Shi Jiang
    Monatshefte für Chemie - Chemical Monthly, 2021, 152 : 19 - 33
  • [2] Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α
    Lo Monte, Fabio
    Kramer, Thomas
    Gu, Jiamin
    Anumala, Upendra Rao
    Marinelli, Luciana
    La Pietra, Valeria
    Novellino, Ettore
    Franco, Benedicte
    Demedts, David
    Van Leuven, Fred
    Fuertes, Ana
    Manuel Dominguez, Juan
    Plotkin, Batya
    Eldar-Finkelman, Hagit
    Schmidt, Boris
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (09) : 4407 - 4424
  • [3] Selective inhibitors of glycogen synthase kinase-3
    Tranter, D
    DRUG DISCOVERY TODAY, 2001, 6 (03) : 158 - 158
  • [4] Studies of glycogen synthase kinase-3 inhibitors
    Zhang Na
    Jiang Yongjun
    Yu Qingsen
    Zou Jianwei
    PROGRESS IN CHEMISTRY, 2007, 19 (04) : 614 - 623
  • [5] Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors
    Avila, Jesus
    Wandosell, Francisco
    Hernandez, Felix
    EXPERT REVIEW OF NEUROTHERAPEUTICS, 2010, 10 (05) : 703 - 710
  • [6] A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies
    Thapa, Riya
    Gupta, Gaurav
    Bhat, Asif Ahmad
    Almalki, Waleed Hassan
    Alzarea, Sami I.
    Kazmi, Imran
    Saleem, Shakir
    Khan, Ruqaiyah
    Altwaijry, Najla
    Dureja, Harish
    Singh, Sachin Kumar
    Dua, Kamal
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 253
  • [7] Construction of the pharmacophore model of glycogen synthase kinase-3 inhibitors
    Liu, Ling
    Zhang, Li-Na
    Jiang, Feng-Chao
    CHINESE JOURNAL OF CHEMISTRY, 2007, 25 (07) : 892 - 897
  • [8] The insulin mimetic action of Glycogen Synthase Kinase-3 inhibitors
    Eldar-Finkelman, H
    Kaidanovich, O
    Plotkin, B
    Talior, I
    DIABETOLOGIA, 2002, 45 : A70 - A70
  • [9] Screening of inhibitors of Taenia solium glycogen synthase Kinase-3β
    Wang, Li
    Cheng, Jiagao
    Wang, Shuai
    Zhang, Xichen
    Cai, Xuepeng
    RSC ADVANCES, 2017, 7 (68): : 43319 - 43326
  • [10] Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
    Hulcova, Daniela
    Breiterova, Katerina
    Siatka, Tomas
    Klimova, Kamila
    Davani, Lara
    Safratova, Marcela
    Host'alkova, Anna
    De Simone, Angela
    Andrisano, Vincenza
    Cahlikova, Lucie
    MOLECULES, 2018, 23 (04):
12345