An updated research of glycogen synthase kinase-3β inhibitors: a review

被引：5

作者：

Liu, Shan-Kui ^{[1
]}

Xie, Hong-Xu ^{[1
]}

Ge, Yong-Xi ^{[1
]}

Zhang, Juan ^{[1
]}

Jiang, Cheng-Shi ^{[1
]}

机构：

[1] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China

来源：

MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 01期

关键词：

GSK-3 beta inhibitor; Rational design; Multi-target; Selectivity; Structure-activity relationship; GSK-3; INHIBITORS; KINASE; 3-BETA; DISCOVERY; CURCUMIN; 1,2,3-TRIAZOLES; DERIVATIVES; DESIGN; POTENT;

D O I：

10.1007/s00706-020-02718-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycogen synthase kinase-3 beta (GSK-3 beta) is a highly conserved multifunctional serine/threonine (Ser/Thr) protein kinase widely expressed in many tissues. GSK-3 beta inhibitors could be used in the treatment of human key diseases, such as cancer, Alzheimer's disease, Parkinson's disease, inflammation, type-II diabetes, and so on, due to the multi-role of GSK-3 beta in the hepatic glycolysis regulation, cell signaling pathways, and phosphorylation of various proteins. Recently, sets of diverse GSK-3 beta inhibitors have been prepared, and biologically evaluated in vitro and in vivo in different screening models. This review summarizes the latest developments in GSK-3 beta inhibitors unclosed from 2015 to 2019, including their structure-activity relationship and bioactivity studies.

引用

页码：19 / 33

页数：15

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