Detection of BRAFV600E Mutation on Papillary Thyroid Carcinoma and Metastatic Malignant Melanoma by Fine-Needle Aspiration Cytology: How Genetic Testing May Drive Toward Personalized Medicine

被引：2

作者：

Rocca, Bruno Jim ^{[1
]}

Ambrosio, Maria Raffaella ^{[1
]}

Ginori, Alessandro ^{[1
]}

Disanto, Andrea ^{[2
]}

机构：

[1] Univ Siena, Sect Pathol, Dept Med Biotechnol, I-53100 Siena, Italy

[2] Azienda Osped Univ Senese, Unit Pathol, Siena, Italy

来源：

DIAGNOSTIC CYTOPATHOLOGY | 2014年 / 42卷 / 10期

关键词：

papillary thyroid carcinoma; malignant melanoma; BRAF; BRAF MUTATIONS; CANCER; RET/PTC; HORMONE;

D O I：

10.1002/dc.23060

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A genetic link between cutaneous melanoma and thyroid cancer (TC) has been identified. A high percentage of both melanomas and papillary carcinomas of the thyroid harbors a recurrent mutation (i.e., BRAF(V600E)) in the BRAF oncogene. Herein, we report the case of a 65-year-old man with papillary TC and cutaneous malignant melanoma metastatic to masseter muscle, both characterized by BRAF mutation. This is one of the rare reports in which a complete molecular characterization has been performed. As the patients with papillary thyroid carcinoma have a higher risk of malignant melanoma and vice versa, continuous monitoring of such patients, with either of these tumors is necessary. Fine-needle aspiration cytology is useful as shown in the present case. Diagn. Cytopathol. 2014;42:877-879. (c) Wiley Periodicals, Inc.

引用

页码：877 / 879

页数：3

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