Tetanus in Southern Vietnam: Current Situation

被引：16

作者：

Duong Bich Thuy ^{[1
,2
,3
]}

Campbell, James I. ^{[2
,3
]}

Tran Tan Thanh ^{[2
]}

Cao Thu Thuy ^{[2
]}

Huynh Thi Loan ^{[1
]}

Nguyen Van Hao ^{[1
]}

Yen Lam Minh ^{[2
]}

Le Van Tan ^{[2
,3
]}

Boni, Maciej F. ^{[2
,3
]}

Thwaites, C. Louise ^{[2
,3
]}

机构：

[1] Hosp Trop Dis, Ho Chi Minh City, Vietnam

[2] Oxford Univ Clin Res Unit, Ho Chi Minh City, Vietnam

[3] Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2017年 / 96卷 / 01期

基金：

英国惠康基金;

关键词：

NEONATAL TETANUS; VACCINATION; PROGRAM; IMPACT;

D O I：

10.4269/ajtmh.16-0470

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In Vietnam, there are no accurate data on tetanus incidence to allow assessment of disease burden or vaccination program efficacy. We analyzed age structure of 786 tetanus cases admitted to a tertiary referral center in Vietnam for three separate years during an 18-year period to examine the impact of tetanus prevention programs, namely the Expanded Program on Immunization (EPI) and the Maternal and Neonatal Tetanus (MNT) initiative. Most cases were born before the initiation of EPI. Median age increased from 33 (interquartile range: 20-52) in 1994, to 46 (32-63) in 2012 (P < 0.001). Birth-year distribution was unchanged, indicating the same birth cohorts presented with tetanus in 1994, 2003, and 2012. Enzyme-linked immunosorbent assay measurements in 90 men and 90 women covered by MNT but not EPI showed 73.3% (95% confidence interval [CI]: 62.9-82.1%) of women had anti-tetanus antibody compared with 24.4% (95% CI: 15.9-34.7%) of men, indicating continued tetanus vulnerability in older men in Vietnam.

引用

页码：93 / 96

页数：4

共 19 条

[1] Levels and avidity of antibodies to tetanus toxoid in children aged 1-15 years in Dar es Salaam and Bagamoyo, Tanzania [J].

Aboud, S ;

Matre, R ;

Lyamuya, EF ;

Kristoffersen, EK .

ANNALS OF TROPICAL PAEDIATRICS, 2000, 20 (04) :313-322

[2]

[Anonymous], 2013, WORLD HLTH STAT

[3] Population-Level Antibody Estimates to Novel Influenza A/H7N9 [J].

Boni, Maciej F. ;

Nguyen Van Vinh Chau ;

Nguyen Dong ;

Todd, Stacy ;

Nguyen Thi Duy Nhat ;

de Bruin, Erwin ;

van Beek, Janko ;

Nguyen Tran Hien ;

Simmons, Cameron P. ;

Farrar, Jeremy ;

Koopmans, Marion .

JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (04) :554-558

[4]

Borrow R, 2006, IMMUNOLOGICAL BASIS

[5]

Expanded Program on Immunizations, 2009, NAT EPI REV REV VIET

[6]

General Statistics Office of Vietnam, 2016, POP EMPL

[7] Incidence and Risk Factors for Neonatal Tetanus in Admissions to Kilifi County Hospital, Kenya [J].

Ibinda, Fredrick ;

Bauni, Evasius ;

Kariuki, Symon M. ;

Fegan, Greg ;

Lewa, Joy ;

Mwikamba, Monica ;

Boga, Mwanamvua ;

Odhiambo, Rachael ;

Mwagandi, Kiponda ;

Seale, Anna C. ;

Berkley, James A. ;

Dorfman, Jeffrey R. ;

Newton, Charles R. J. C. .

PLOS ONE, 2015, 10 (04)

[8] Thirty years of vaccination in Vietnam: Impact and cost-effectiveness of the national Expanded Programme on Immunization [J].

Jit, Mark ;

Dang Thi Thanh Huyen ;

Friberg, Ingrid ;

Hoang Van Minh ;

Pham Huy Tuan Kiet ;

Walker, Neff ;

Nguyen Van Cuong ;

Tran Nhu Duong ;

Toda, Kohei ;

Hutubessy, Raymond ;

Fox, Kimberley ;

Nguyen Tran Hien .

VACCINE, 2015, 33 :A233-A239

[9] Maternal and neonatal tetanus elimination: from protecting women and newborns to protecting all [J].

Khan, Rownak ;

Vandelaer, Jos ;

Yakubu, Ahmadu ;

Raza, Azhar Abid ;

Zulu, Flint .

INTERNATIONAL JOURNAL OF WOMENS HEALTH, 2015, 7 :171-180

[10] Prognosis of neonatal tetanus in the modern management era: an observational study in 107 Vietnamese infants [J].

Phung Khanh Lam ;

Trieu, Huynh T. ;

Lubis, Inke Nadia D. ;

Loan, Huynh T. ;

Tran Thi Diem Thuy ;

Wills, Bridget ;

Parry, Christopher M. ;

Day, Nicholas P. J. ;

Qui, Phan T. ;

Lam Minh Yen ;

Thwaites, C. Louise .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2015, 33 :7-11

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