Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States

被引：19
作者：
Krapp, Fiorella [1 ]
Ozer, Egon A. [1 ]
Qi, Chao [2 ]
Hauser, Alan R. [1 ,3 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Infect Dis, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
[3] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 05期
关键词：
Klebsiella pneumoniae; antibiotic resistance; resistance genes; extensively drug-resistant; COLISTIN-RESISTANT; TIGECYCLINE; COMBINATION; AZTREONAM;
D O I：
10.1093/ofid/ofy074
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Reports of extensively drug-resistant and pan-drug-resistant Klebsiella pneumoniae (XDR-KP and PDR-KP) cases are increasing worldwide. Here, we report a case of XDR-KP with an in-depth molecular characterization of resistance genes using whole-genome sequencing, and we review all cases of XDR-KP and PDR-KP reported in the United States to date.
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页数：5
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共 20 条
  • [1] Predictability of Phenotype in Relation to Common β-Lactam Resistance Mechanisms in Escherichia coli and Klebsiella pneumoniae
    Agyekum, Alex
    Fajardo-Lubian, Alicia
    Ai, Xiaoman
    Ginn, Andrew N.
    Zong, Zhiyong
    Guo, Xuejun
    Turnidge, John
    Partridge, Sally R.
    Iredell, Jonathan R.
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2016, 54 (05) : 1243 - 1250
  • [2] [Anonymous], 2017, ANTIMICROB AGENTS CH
  • [3] Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call
    Bathoorn, E.
    Tsioutis, C.
    Voorham, J. M. da Silva
    Scoulica, E. V.
    Ioannidou, E.
    Zhou, K.
    Rossen, J. W.
    Gikas, A.
    Friedrich, A. W.
    Grundmann, H.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (05) : 1207 - 1212
  • [4] Extensively Drug-Resistant Klebsiella pneumoniae Causing Nosocomial Bloodstream Infections in China: Molecular Investigation of Antibiotic Resistance Determinants, Informing Therapy, and Clinical Outcomes
    Bi, Wenzi
    Liu, Haiyang
    Dunstan, Rhys A.
    Li, Bin
    Torres, Von Vergel L.
    Cao, Jianming
    Chen, Lijiang
    Wilksch, Jonathan J.
    Strugnell, Richard A.
    Lithgow, Trevor
    Zhou, Tieli
    [J]. FRONTIERS IN MICROBIOLOGY, 2017, 8
  • [5] In Vitro Selection of ramR and soxR Mutants Overexpressing Efflux Systems by Fluoroquinolones as Well as Cefoxitin in Klebsiella pneumoniae
    Bialek-Davenet, Suzanne
    Marcon, Estelle
    Leflon-Guibout, Veronique
    Lavigne, Jean-Philippe
    Bert, Frederic
    Moreau, Richard
    Nicolas-Chanoine, Marie-Helene
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (06) : 2795 - 2802
  • [6] Colistin-Resistant, Klebsiella pneumoniae Carbapenemase (KPC)-Producing Klebsiella pneumoniae Belonging to the International Epidemic Clone ST258
    Bogdanovich, Tatiana
    Adams-Haduch, Jennifer M.
    Tian, Guo-Bao
    Minh Hong Nguyen
    Kwak, Eun Jeong
    Muto, Carlene A.
    Doi, Yohei
    [J]. CLINICAL INFECTIOUS DISEASES, 2011, 53 (04) : 373 - 376
  • [7] Pan-Resistant New Delhi Metallo-Beta-Lactamase-Producing Klebsiella pneumoniae - Washoe County, Nevada, 2016
    Chen, Lei
    Todd, Randall
    Kiehlbauch, Julia
    Walters, Maroya
    Kallen, Alexander
    [J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2017, 66 (01): : 33 - 33
  • [8] Infection with Panresistant Klebsiella pneumoniae: A Report of 2 Cases and a Brief Review of the Literature
    Elemam, Azza
    Rahimian, Joseph
    Mandell, William
    [J]. CLINICAL INFECTIOUS DISEASES, 2009, 49 (02) : 271 - 274
  • [9] Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin
    Humphries, Romney M.
    Kelesidis, Theodoros
    Bard, Jennifer Dien
    Ward, Kevin W.
    Bhattacharya, Debika
    Lewinski, Michael A.
    [J]. JOURNAL OF MEDICAL MICROBIOLOGY, 2010, 59 (11) : 1383 - 1386
  • [10] Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae
    Jayol, Aurelie
    Nordmann, Patrice
    Poirel, Laurent
    Dubois, Veronique
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (02) : 542 - 544
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