Treatment of early and locally advanced stages of non-small cell lung cancer

被引：0

作者：

Wiesweg, Marcel ^{[1
,2
]}

Eberhardt, Wilfried E. ^{[1
,2
]}

Schuler, Martin ^{[1
,2
]}

Ploenes, Till ^{[3
]}

机构：

[1] Univ Duisburg Essen, Univ Klinikum Essen, Innere Klin Tumorforsch, Westdeutsch Tumorzentrum, Hufelandstr 55, D-45147 Essen, Germany

[2] Univ Duisburg Essen, Univ Med Essen, Thorakale Onkol, Westdeutsch Tumorzentrum,Ruhrlandklin, Essen, Germany

[3] Univ Duisburg Essen, Klin Thoraxchirurg & Thorakale Endoskopie, Westdeutsch Tumorzentrum, Univ Med Essen,Ruhrlandklin, Essen, Germany

来源：

INNERE MEDIZIN | 2022年 / 63卷 / 07期

关键词：

Immune checkpoint inhibitors; Chemotherapy; adjuvant; Radiotherapy; Combined modality therapy; Immunotherapy; preoperative; ADJUVANT CHEMOTHERAPY; PHASE-III; CISPLATIN; SURVIVAL; CHEMORADIOTHERAPY; ASSOCIATION; VINORELBINE; RESECTION; THERAPY; TRIAL;

D O I：

10.1007/s00108-022-01366-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment concepts for patients with localized and locally advanced non-small cell lung cancer (NSCLC) are based on local treatment, surgery and/or radiotherapy, with curative intent. An adjuvant systemic treatment is added after primary resection of an operable NSCLC primarily to reduce the systemic risk of relapse. Locally advanced stages with mediastinal lymph node involvement carry a substantial risk of local and distant recurrence and require multimodal treatment strategies in an interdisciplinary approach. Recently, immunotherapy with programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) checkpoint inhibitors is increasingly being integrated into adjuvant, neoadjuvant or perioperative treatment concepts.

引用

页码：717 / 723

页数：7

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