An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets

被引：21
作者：
Ward, Daniel [1 ]
Higgins, Matthew [1 ]
Phelan, Jody E. [1 ]
Hibberd, Martin L. [1 ]
Campino, Susana [1 ]
Clark, Taane G. [1 ,2 ]
机构：
[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect Biol, Keppel St, London WC1E 7HT, England
[2] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Keppel St, London WC1E 7HT, England
来源：
GENOME MEDICINE | 2021年 / 13卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
SARS-CoV-2; COVID; Human-coronavirus; Immuno-informatics; Mutation; Epitopes; Cross-reactivity; Surveillance; RESPIRATORY SYNDROME SARS; T-CELLS; CORONAVIRUS; RESPONSES; PREDICTION; PROTECTION; ANTIBODIES; EPITOPES;
D O I：
10.1186/s13073-020-00822-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online "immuno-analytics" resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from: (online); (source code).
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页数：12
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