PPI INDUCED RENAL TOXICITY

PPIs are mostly used drugs in many prescriptions along with drugs for other co-morbidities and also used for long time periods and as OTC drugs (medication). These drugs on prolong use causes renal toxicity in many cases by affecting glomerular filtration and also through several cases like increase in pH, gastroenteritis, hyperplasia, hypertrophy, hypergastrinemia, hyperchlorhydria, and effect on mitochondrial cells. The unrequited actions by PPIs also can appear in paediatrics along with adults. In this paper we will review about brief information regarding pharmacokinetics and pharmacodynamics of proton pump inhibitors and those several adverse pathways, physiologies and the alternative to prevent these conditions.