Opportunities and challenges in liquid cell electron microscopy

被引：470
作者：
Ross, Frances M. [1 ]
机构：
[1] IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA
来源：
SCIENCE | 2015年 / 350卷 / 6267期
基金：
美国国家科学基金会;
关键词：
IN-SITU OBSERVATION; LI-ION BATTERIES; NANOCRYSTAL GROWTH; MORPHOLOGICAL EVOLUTION; NANOPARTICLE DYNAMICS; LEAD DENDRITES; NUCLEATION; GRAPHENE; WATER; RESOLUTION;
D O I：
10.1126/science.aaa9886
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Transmission electron microscopy offers structural and compositional information with atomic resolution, but its use is restricted to thin, solid samples. Liquid samples, particularly those involving water, have been challenging because of the need to form a thin liquid layer that is stable within the microscope vacuum. Liquid cell electron microscopy is a developing technique that allows us to apply the powerful capabilities of the electron microscope to imaging and analysis of liquid specimens. We describe its impact in materials science and biology.We discuss how its applications have expanded via improvements in equipment and experimental techniques, enabling new capabilities and stimuli for samples in liquids, and offering the potential to solve grand challenge problems.
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页数：10
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