Improved Chemosensitization Activity of Carboxymethyl Chitosan/PVA Hydrogels by Plasma Surface Modification

被引:11
作者
Dalei, Ganeswar [1 ]
Das, Subhraseema [1 ]
Jena, Soumya Ranjan [2 ]
Nayak, Jasmine [2 ]
Samanta, Luna [2 ]
Das, Smruti Prava [1 ]
机构
[1] Ravenshaw Univ, Dept Chem, Plasma Res Lab, Cuttack 753003, Odisha, India
[2] Ravenshaw Univ, Dept Zool, Redox Biol Lab, Cuttack 753003, Odisha, India
关键词
Carboxymethyl chitosan; PVA; Cold plasma; Chemosensitivity; Hemocompatibility; CHITOSAN/POLY(VINYL ALCOHOL) HYDROGELS; NONTHERMAL PLASMA; ATMOSPHERIC-PRESSURE; DELIVERY; RELEASE; DRUG; ALGINATE; MECHANISMS; NANOFIBERS; EMISSION;
D O I
10.1007/s10924-020-02007-z
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
As global population escalates; the need for better healthcare shall inevitably intensify. Current scenario, thus, calls for a versatile technology for the construction for smart biomaterials to cater to the needs. In this context; hydrogels comprising carboxymethyl chitosan and polyvinyl alcohol (CMCS/ PVA) were fabricated using a green crosslinker, tetraethyl orthosilicate. To enhance their bio-efficacy; cold plasma assisted surface tailoring of the aforesaid hydrogels was performed as a function of four different gases viz Air, Ar, He and N-2. Apart from improving the surface wettability; plasma treatment endowed the hydrogels with an improved tensile strength. 5-Fluorouracil (5FU) release studies from the hydrogels validated their potential as oral colon-targeted delivery systems. Hemolytic experiments revealed no adverse effect on RBCs post-plasma treatment. Pristine hydrogels exhibited good cytocompatibility with MCF-7 cells. A strong cell growth inhibition was observed from 5FU-loaded hydrogels as validated by caspase-3 assay. Further assessment by the soil burial test revealed the hydrogels were biodegradable. Among all, the Ar-plasma treated hydrogel demonstrated superior hemocompatibility, chemosensitivity and biodegradability. Thus, cold plasma technology has invariably paved the path as an eco-friendly, economical and effectual strategy for development of novel CMCS/ PVA hydrogels in anticancer therapy.
引用
收藏
页码:1663 / 1679
页数:17
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