Characterization of Susceptibility Variants of Influenza Virus Grown in the Presence of T-705

被引：22

作者：

Daikoku, Tohru ^{[1
]}

Yoshida, Yoshihiro ^{[1
]}

Okuda, Tomoko ^{[1
]}

Shiraki, Kimiyasu ^{[1
]}

机构：

[1] Toyama Univ, Dept Virol, Toyama 9300194, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2014年 / 126卷 / 03期

基金：

日本学术振兴会;

关键词：

influenza virus; T-705; favipiravir; RNA-POLYMERASE; IN-VITRO; SUBUNIT; ACYCLOVIR; FAVIPIRAVIR; RESISTANCE; PB2;

D O I：

10.1254/jphs.14156SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strain had amino acid variations in the PB1, PB2, and PA genes of the RNA polymerase complex. However, the variation patterns in the RNA polymerase complex indicated that T-705 does not work as a mutagen, and resistant mutants were not isolated, possibly because a mutation leading to resistance would be lethal to the RNA polymerase function.

引用

页码：281 / 284

页数：4