Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers

被引:31
作者
Liu, Shao Qiong [1 ]
Venkataraman, Shrinivas [1 ]
Ong, Zhan Yuin [1 ]
Chan, Julian M. W. [2 ]
Yang, Chuan [1 ]
Hedrick, James L. [2 ]
Yang, Yi Yan [1 ]
机构
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[2] IBM Almaden Res Ctr, San Jose, CA 95120 USA
关键词
small cationic oligomers; self-assembly; nanostructures; antimicrobial; multidrug resistance; HOST-DEFENSE PEPTIDES; ANTIMICROBIAL PEPTIDES; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; ANTIBACTERIAL; BACTERIA; NANOPARTICLES; DERIVATIVES; SELECTIVITY; HYDROGEL;
D O I
10.1002/smll.201303921
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A study was conducted to report the synthesis, self-assembly and antimicrobial activity of a series of novel oligomeric cationic compounds of discrete molecular weights. These compounds were designed with a rigid hydrophobic terephthalamidebis urea core flanked by hydrophilic imidazolium groups with short alkyl or simple aryl tails, and were found to readily self-assemble into nanostructures in aqueous solutions. The cationic oligomer with optimal hydrophobic/hydrophilic balance showed potent, broad-spectrum antimicrobial activity and high selectivity towards Gram-positive bacteria, killing the microbes via the membrane-lytic mechanism. The key design element of our cationic antimicrobial oligomers was based on the rigid terephthalamide core generated via the organocatalytic aminolysis of poly(ethylene terephthalate) (PET) with 4-aminobenzylamine and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) .
引用
收藏
页码:4130 / 4135
页数:6
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