TTI-622 (SIRPα-IgG4 Fc), a CD47-blocking innate immune checkpoint inhibitor, suppresses tumor growth and demonstrates enhanced efficacy in combination with antitumor antibodies in both hematologic and solid tumor models

被引:9
|
作者
Lin, Gloria H. Y. [1 ]
Viller, Natasja N. [1 ]
Chabonneau, Marilyse [1 ]
Brinen, Laura [1 ]
Mutukura, Tapfuma [1 ]
Dodge, Karen [1 ]
Helke, Simone [1 ]
Chai, Vien [1 ]
House, Violetta [1 ]
Lee, Vivian [1 ]
Chen, Hui [1 ]
O'Connor, Alison [1 ]
Jin, Debbie [1 ]
Figueredo, Rene [2 ]
Vareki, Saman Maleki [2 ]
Wong, Mark [1 ]
Linderoth, Emma [1 ]
Johnson, Lisa D. [1 ]
Pang, Xinli [1 ]
Koropatnick, James [2 ]
Winston, Jeff [1 ]
Petrova, Penka S. [1 ]
Uger, Robert A. [1 ]
机构
[1] Trillium Therapeut Inc, Mississauga, ON, Canada
[2] Lawson Hlth Res Inst, London, ON, Canada
关键词
D O I
10.1158/1538-7445.AM2018-2709
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2709
引用
收藏
页数:2
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