Thrombocytopenia and thrombosis in hospitalized patients with COVID-19

被引：70

作者：

Mei, Heng ^{[1
,2
]}

Luo, Lili ^{[1
,2
]}

Hu, Yu ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Inst Haematol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China

[2] Hubei Clin & Res Ctr Thrombosis & Hemostasis, Wuhan, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2020年 / 13卷 / 01期

关键词：

COVID-19; Thrombocytopenia; Thrombosis;

D O I：

10.1186/s13045-020-01003-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As our understanding on coronavirus disease 2019 (COVID-19) deepens, it is increasingly recognized that COVID-19 is more than a respiratory condition. Thrombocytopenia and thromboembolic complications are a composite factor associated with critical COVID-19 and increased mortality. Immune-inflammation-mediated destruction, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection per se and increased consumption are proposed to be responsible for thrombocytopenia. Multiple concomitant conditions or results caused by SARS-CoV-2 infection are high risk factors for thrombosis. Recently, platelet activation and platelet-mediated immune inflammation induced by SARS-CoV-2 infection were also found to be the contributors to the thrombosis in COVID-19 patients. In addition to thrombus scoring system, D-dimer is an excellent indicator for monitoring thrombosis. COVID-19 patients with high risk for thrombosis should be subjected to early thromboprophylaxis, and prolonged activated partial-thromboplastin time should not be a barrier to the use of anticoagulation therapies in the control of thrombosis in COVID-19 patients.

引用

页数：3

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