Aortic valve calcification: basic science to clinical practice

被引:74
作者
Akat, K. [1 ]
Borggrefe, M. [1 ]
Kaden, J. J. [1 ]
机构
[1] Heidelberg Univ, Fac Med, Dept Med Cardiol 1, D-68167 Mannheim, Germany
关键词
ANGIOTENSIN-CONVERTING ENZYME; LOW-DENSITY-LIPOPROTEIN; MATRIX-METALLOPROTEINASE EXPRESSION; VALVULAR HEART-DISEASE; FACTOR-KAPPA-B; INTERSTITIAL-CELLS; RECEPTOR ACTIVATOR; VASCULAR CALCIFICATION; LINE CHARACTERISTICS; METABOLIC SYNDROME;
D O I
10.1136/hrt.2007.134783
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Calcific aortic valve stenosis is the result of regulated cell processes. The histological hallmarks are inflammation and a remodelling of the extracellular matrix leading to bone formation. In the last 15 years the view has changed from it being an unmodifiable degenerative disease to an active biological process regulated by highly conserved ubiquitous cellular pathways. Many mechanisms and risk factors are the same as in atherosclerosis. Thus, statins and angiotensin II antagonists seemed promising treatment options. However, clinical trials failed to support this. This review describes the current understanding of major molecular mechanisms and discusses their role in clinical practice and possible therapy.
引用
收藏
页码:616 / 623
页数:8
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