Applications of Gelatin Methacryloyl (GelMA) Hydrogels in Microfluidic Technique-Assisted Tissue Engineering

被引：62

作者：

Liu, Taotao ^{[1
]}

Weng, Wenxian ^{[1
]}

Zhang, Yuzhuo ^{[1
]}

Sun, Xiaoting ^{[2
]}

Yang, Huazhe ^{[3
]}

机构：

[1] China Med Univ, Sch Fundamental Sci, Dept Biomed Engn, Shenyang 110122, Peoples R China

[2] China Med Univ, Sch Fundamental Sci, Dept Chem, Shenyang 110122, Peoples R China

[3] China Med Univ, Sch Fundamental Sci, Dept Biophys, Shenyang 110122, Peoples R China

来源：

MOLECULES | 2020年 / 25卷 / 22期

基金：

中国国家自然科学基金;

关键词：

GelMA hydrogels; microfluidics; biomedicine; PHOTOCROSSLINKABLE GELATIN; MICROENGINEERED HYDROGELS; STEM-CELLS; FABRICATION; CONSTRUCTS; CHIP; MICROFIBERS; SCAFFOLDS; MICROFABRICATION; PLATFORM;

D O I：

10.3390/molecules25225305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed.

引用

页数：16

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