Primary Cutaneous Anaplastic Large Cell Lymphoma With Gastric Metastasis

被引：4

作者：

Khrais, Ayham ^{[1
]}

Abboud, Yazan ^{[1
]}

Le, Alexander ^{[1
]}

Patel, Param ^{[2
]}

Vossough-Teehan, Sima ^{[3
]}

机构：

[1] Rutgers Univ New Jersey, Dept Med, Sch Med, Piscataway, NJ 08854 USA

[2] Rutgers Univ New Jersey, Dept Gastroenterol & Hepatol, Sch Med, Newark, NJ USA

[3] E Orange Vet Affairs Med Ctr, Dept Gastroenterol & Hepatol, E Orange, NJ USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 12期

关键词：

extranodal nk; t cell lymphoma; metastatic malignancy; cutaneous t -cell lymphoma; non hodgkin's; lymphoma; primary cutaneous lymphomas;

D O I：

10.7759/cureus.32922

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a subtype of non-Hodgkin lymphoma (NHL) that is localized to the skin. Disseminated disease is rare, and visceral organ involvement is even more so. We report a unique case of PCALCL with gastric metastasis. A 75-year-old man with a history of cutaneous left lower extremity PCALCL status post radiation therapy initially presented with abdominal pain and was found to have diffuse celiac axis and retroperitoneal lymphadenopathy. Endoscopy, initially done to biopsy an involved lymph node (LN), demonstrated a friable gastric nodular lesion with telangiectasias. Biopsy of the lesion and LN revealed anaplastic large cell lymphoma, identical in pathology to the known skin lesion. The patient was treated with systemic chemotherapy with a good response. PCALCL has been thought of as a localized malignancy with a good prognosis and low potential for extracutaneous spread. To our knowledge, this is the first instance of metastatic PCALCL involving the stomach.

引用

页数：5

共 10 条

[1]

Benner MF, 2009, ARCH DERMATOL, V145, P1399, DOI 10.1001/archdermatol.2009.280

[2] Primary cutaneous anaplastic large cell lymphoma [J].

Brown, Ryanne A. ;

Fernandez-Pol, Sebastian ;

Kim, Jinah .

JOURNAL OF CUTANEOUS PATHOLOGY, 2017, 44 (06) :570-577

[3] Prognostic factors in patients with primary cutaneous anaplastic large cell lymphoma: a multicentric, retrospective analysis of the Spanish Group of Cutaneous Lymphoma [J].

Fernandez-de-Misa, R. ;

Hernandez-Machin, B. ;

Combalia, A. ;

Garcia Muret, M. P. ;

Servitje, O. ;

Muniesa, C. ;

Gallardo, F. ;

Pujol, R. M. ;

Marti, R. M. ;

Ortiz-Brugues, A. ;

Maronas-Jimenez, L. ;

Ortiz-Romero, P. L. ;

Blanch Rius, L. ;

Izu, R. ;

Roman, C. ;

Canueto, J. ;

Blanes, M. ;

Morillo, M. ;

Bastida, J. ;

Penate, Y. ;

Perez Gala, S. ;

Espinosa Lara, P. ;

Perez Gil, A. ;

Estrach, T. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 34 (04) :762-768

[4] Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial [J].

Horwitz, Steven ;

O'Connor, Owen A. ;

Pro, Barbara ;

Illidge, Tim ;

Fanale, Michelle ;

Advani, Ranjana ;

Bartlett, Nancy L. ;

Christensen, Jacob Haaber ;

Morschhauser, Franck ;

Domingo-Domenech, Eva ;

Rossi, Giuseppe ;

Kim, Won Seog ;

Feldman, Tatyana ;

Lennard, Anne ;

Belada, David ;

Illes, Arpad ;

Tobinai, Kensei ;

Tsukasaki, Kunihiro ;

Yeh, Su-Peng ;

Shustov, Andrei ;

Huttmann, Andreas ;

Savage, Kerry J. ;

Yuen, Sam ;

Iyer, Swaminathan ;

Zinzani, Pier Luigi ;

Hua, Zhaowei ;

Little, Meredith ;

Rao, Shangbang ;

Woolery, Joseph ;

Manley, Thomas ;

Trumper, Lorenz ;

Aboulafia, David ;

Alpdogan, Onder ;

Ando, Kiyoshi ;

Arcaini, Luca ;

Baldini, Luca ;

Bellam, Naresh ;

Bartlett, Nancy ;

Ben Yehuda, Dina ;

Benedetti, Fabio ;

Borchman, Peter ;

Bordessoule, Dominique ;

Brice, Pauline ;

Briones, Javier ;

Caballero, Dolores ;

Carella, Angelo Michele ;

Chang, Hung ;

Cheong, June Weon ;

Cho, Seok-Goo ;

Choi, Ilseung .

LANCET, 2019, 393 (10168) :229-240

[5] Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management [J].

Psyrri, A. ;

Papageorgiou, S. ;

Economopoulos, T. .

ANNALS OF ONCOLOGY, 2008, 19 (12) :1992-1999

[6] Cutaneous T-cell Lymphoma [J].

Pulitzer, Melissa .

CLINICS IN LABORATORY MEDICINE, 2017, 37 (03) :527-+

[7] Mycosis fungoides and gastric T-cell lymphoma: A case report [J].

Scali, Elisabetta ;

Presta, Ivan ;

Donato, Annalidia ;

Schipani, Giusy ;

Dastoli, Stefano ;

Rossi, Marco ;

Mignogna, Chiara ;

Malara, Natalia ;

Nistico, Steven Paul ;

Donato, Giuseppe .

MOLECULAR AND CLINICAL ONCOLOGY, 2020, 13 (03) :1-6

[8] A case of primary gastric CD30-positive anaplastic large-cell lymphoma [J].

Song, HH ;

Baik, GH ;

Kwon, JH ;

Lee, KS ;

Choi, YH ;

Choi, KC ;

Park, YE .

JOURNAL OF KOREAN MEDICAL SCIENCE, 2005, 20 (06) :1062-1065

[9] Cutaneous T-Cell Lymphoma: Two Faces of the Same Coin [J].

Wozniak, Magdalena B. ;

Piris, Miguel A. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (02) :348-351

[10] Anaplastic Large Cell Lymphomas: ALK Positive, ALK Negative, and Primary Cutaneous [J].

Xing, Xiaoming ;

Feldman, Andrew L. .

ADVANCES IN ANATOMIC PATHOLOGY, 2015, 22 (01) :29-49

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