Flipping the oncogene switch - illumination of tumor maintenance and regression

被引：23
作者：
Chin, L
DePinho, RA
机构：
[1] Harvard Univ, Sch Med, Dept Adult Oncol, Dana Farber Canc Inst,Dept Dermatol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med & Genet, Boston, MA 02115 USA
来源：
TRENDS IN GENETICS | 2000年 / 16卷 / 04期
关键词：
D O I：
10.1016/S0168-9525(99)01968-X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The genetic construction of cancer-prone mice, combined with the capacity to control transgene expression in vivo, provides new opportunities to study the role of oncogenes in the maintenance of fully formed tumors. These inducible cancer models provide a means to dissect how specific oncogenic signals influence host-tumor symbiosis, to validate the importance of a given oncogenic lesion in established advanced tumors, and to predict the biological response and adaptations to therapies targeted to that cancer-causing genetic alteration.
引用
收藏
页码：147 / 150
页数：4
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