Prostate-specific Membrane Antigen-targeted Ligand Positron Emission Tomography/Computed Tomography and Immunohistochemical Findings in a Patient With Synchronous Metastatic Penile and Prostate Cancer

被引：9
作者：
Froehner, Michael [1 ]
Kuithan, Friederike
Zoephel, Klaus
Heberling, Ulrike
Laniado, Michael
Wirth, Manfred P.
机构：
[1] Tech Univ Dresden, Dept Urol, Univ Hosp Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany
来源：
UROLOGY | 2017年 / 101卷
关键词：
EXPRESSION; CARCINOMA;
D O I：
10.1016/j.urology.2016.11.040
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma. The interpretation of imaging in synchronous tumors should take this fact into consideration. (C) 2016 Elsevier Inc.
引用
收藏
页码：E5 / E6
页数：2
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