Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

被引：115

作者：

Byrareddy, Siddappa N. ^{[1
]}

Kallam, Brianne ^{[1
]}

Arthos, James ^{[2
]}

Cicala, Claudia ^{[2
]}

Nawaz, Fatima ^{[2
]}

Hiatt, Joseph ^{[2
]}

Kersh, Ellen N. ^{[3
]}

McNicholl, Janet M. ^{[3
]}

Hanson, Debra ^{[3
]}

Reimann, Keith A. ^{[4
]}

Brameier, Markus ^{[5
]}

Walter, Lutz ^{[5
]}

Rogers, Kenneth ^{[6
]}

Mayne, Ann E. ^{[1
]}

Dunbar, Paul ^{[1
]}

Villinger, Tara ^{[1
]}

Little, Dawn ^{[1
]}

Parslow, Tristram G. ^{[1
]}

Santangelo, Philip J. ^{[7
,8
]}

Villinger, Francois ^{[1
,6
]}

Fauci, Anthony S. ^{[2
]}

Ansari, Aftab A. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[2] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[3] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA

[4] Univ Massachusetts, Sch Med, Mass Biol, Boston, MA 02125 USA

[5] German Primate Ctr, Leibniz Inst Primate Res, Primate Genet Lab, Gottingen, Germany

[6] Emory Univ, Yerkes Natl Primate Res Ctr, Div Microbiol & Immunol, Atlanta, GA 30322 USA

[7] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[8] Emory Univ, Atlanta, GA 30322 USA

来源：

NATURE MEDICINE | 2014年 / 20卷 / 12期

关键词：

T-CELL SUBSET; MAINTENANCE THERAPY; IMMUNE ACTIVATION; ALPHA-4-BETA-7; VEDOLIZUMAB; INDUCTION; DEPLETION; RECEPTOR; TRACT; CD4;

D O I：

10.1038/nm.3715

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha(4)beta(7) integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-alpha(4)beta(7) monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIVmac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4(+) T cell numbers were maintained in both the blood and the GALT. Thus, targeting alpha(4)beta(7) reduces mucosal transmission of Sly in macaques.

引用

页码：1397 / 1400

页数：4

共 36 条

[1] Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection
Siddappa N Byrareddy
Brianne Kallam
James Arthos
Claudia Cicala
Fatima Nawaz
Joseph Hiatt
Ellen N Kersh
Janet M McNicholl
Debra Hanson
Keith A Reimann
Markus Brameier
Lutz Walter
Kenneth Rogers
Ann E Mayne
Paul Dunbar
Tara Villinger
Dawn Little
Tristram G Parslow
Philip J Santangelo
Francois Villinger
Anthony S Fauci
Aftab A Ansari
Nature Medicine, 2014, 20 : 1397 - 1400
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[3] Evolution of nef variants in gut associated lymphoid tissue of rhesus macaques during primary simian immunodeficiency virus infection
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VIROLOGY, 2005, 343 (01) : 1 - 11
[4] 5-fluorouracil infusion reduces gut-associated lymphoid tissue cell number and mucosal immunoglobulin A levels
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[5] L-selectin and α4β7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice
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[6] Key role played by the gut associated lymphoid tissue during human immunodeficiency virus infection
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M S-MEDECINE SCIENCES, 2015, 31 (12): : 1092 - 1101
[7] An Integrin α4β7.IgG Heterodimeric Chimera Binds to MAdCAM-1 on High Endothelial Venules in Gut-Associated Lymphoid Tissue
Hoshino, Hitomi
Kobayashi, Motohiro
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JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2011, 59 (06) : 572 - 583
[8] PRIMARY ACUTE SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION OF INTESTINAL LYMPHOID-TISSUE IS ASSOCIATED WITH GASTROINTESTINAL DYSFUNCTION
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[9] Gut-Associated Lymphoid Tissue: A Key Tissue inside the Mucosal Immune System of Hens Immunized with Escherichia coli F4
Peralta, Maria F.
Magnoli, Alejandra
Alustiza, Fabrisio
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Miazzo, Raul
Vivas, Adriana
FRONTIERS IN IMMUNOLOGY, 2017, 8
[10] Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis
Canales-Herrerias, Pablo
Uzzan, Mathieu
Seki, Akihiro
Czepielewski, Rafael S.
Verstockt, Bram
Livanos, Alexandra E.
Raso, Fiona
Dunn, Alexandra
Dai, Daniel
Wang, Andrew
Al-taie, Zainab
Martin, Jerome
Laurent, Thomas
Ko, Huaibin M.
Tokuyama, Minami
Tankelevich, Michael
Meringer, Hadar
Cossarini, Francesca
Jha, Divya
Krek, Azra
Paulsen, John D.
Taylor, Matthew D.
Nakadar, Mohammad Zuber
Wong, Joshua
Erlich, Emma C.
Mintz, Rachel L.
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Argmann, Carmen
Petralia, Francesca
Randolph, Gwendalyn J.
Polydorides, Alexandros D.
Reboldi, Andrea
Colombel, Jean-Frederic
Mehandru, Saurabh
SCIENCE IMMUNOLOGY, 2024, 9 (94)

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