Clinical efficacy of narrow-band UVB (311 nm) combined with dithranol in psoriasis -: An open pilot study

被引：14
|
作者：
Carrozza, P [1 ]
Häusermann, P [1 ]
Nestle, FO [1 ]
Burg, G [1 ]
Böni, R [1 ]
机构：
[1] Univ Spital Zurich, Dermatol Klin, Dept Dermatol, CH-8091 Zurich, Switzerland
来源：
DERMATOLOGY | 2000年 / 200卷 / 01期
关键词：
psoriasis; dithranol; narrow band;
D O I：
10.1159/000018312
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: For UVB, the most effective wavelength in clearing psoriatic lesions was found to be of 313 nm. The efficacy of whole body exposure to narrow-band UVB (311 nm) combined with dithranol in psoriasis has not been evaluated to date. Objective: Evaluation of the clinical efficacy of phototherapy with narrow-band UVB (311 nm) and dithranol for psoriasis by means of whole body exposures and analysis of the mean cumulative irradiation dose. Methods: In this open pilot study, 13 patients were treated for 4-5 weeks. Evaluation of the therapeutic efficacy was performed by comparing the Psoriasis Area and Severity Index (PASI) scores at baseline and after 4 weeks of treatment. The cumulative irradiation dose was also calculated. Results: Evaluation of the PASI scores showed a significant overall reduction of psoriatic lesions after 4 weeks of treatment. The cumulative irradiation dose was similar or lower to those found for phototherapy with narrow-band UVB alone, Discussion: In patients with widespread psoriasis, treatment with narrow-band UVB (311 nm) combined with dithranol is safe and effective, allowing reduction of the cumulative irradiation dose. Copyright (R) 2000 S. Karger AG, Basel.
引用
收藏
页码：35 / 39
页数：5
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