IL-18, VCAM-1 and P-selectin as early biomarkers in normoalbuminuric Type 2 diabetes patients

被引：18
|
作者：
Al-Rubeaan, Khalid [1 ]
Nawaz, Shaik S. [2 ]
Youssef, Amira M. [3 ]
Al Ghonaim, Mohammed [4 ]
Siddiqui, Khalid [2 ]
机构：
[1] King Saud Univ, Univ Diabet Ctr, Dept Med, Coll Med, Riyadh, Saudi Arabia
[2] King Saud Univ, Biochem Dept, Strateg Ctr Diabet Res, Riyadh, Saudi Arabia
[3] King Saud Univ, Univ Diabet Ctr, Biochem Dept, Registry Dept, Riyadh, Saudi Arabia
[4] King Saud Univ, King Khalid Universe Hosp, Coll Med, Riyadh, Saudi Arabia
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 06期
关键词：
diabetic kidney disease; diabetic retinopathy; IL-18; low eGFR; pathophysiological role; P-selectin; SAUDI-DKD; Type; 2; diabetes; VCAM-1; YKL-40; CHRONIC KIDNEY-DISEASE; INFLAMMATORY CYTOKINES; DYSFUNCTION; IMPAIRMENT; EXPRESSION; MOLECULES;
D O I：
10.2217/bmm-2018-0359
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To investigate the pathophysiological role of different biomarkers in diabetic kidney disease (DKD) among normoalbuminuric patients with a low-estimated glomerular filtration rate (eGFR). Methods: In this cross-sectional study of 200 normoalbuminuric Type 2 diabetes patients, 28 patients (14%) had a low eGFR. Results: The IL-18, VCAM-1 and P-selectin levels were significantly higher at a low eGFR. On analyzing the area under the receiver operating characteristic curve, these biomarkers had significant diagnostic value and have important pathophysiological role in the progression of DKD. Conclusion: Among normoalbuminuric Type 2 diabetes patients, IL-18, VCAM-1 and P-selectinmay play a significant role in the prediction of early DKD. Further prospective studies need to be conducted to confirm this observation.
引用
收藏
页码：467 / 478
页数：12
相关论文
共 50 条
  • [1] Tetranectin, soluble P-selectin and VCAM-1 in the plasma of children with insulin-dependent diabetes mellitus
    Kamper, EF
    Kopeikina, LT
    Karajiannis, C
    Gourgiotis, D
    Karpathios, T
    Stavridis, JC
    FIBRINOLYSIS & PROTEOLYSIS, 1999, 13 (03): : 148 - 153
  • [2] Circulating ICAM-1, VCAM-1, E-selectin, P-selectin, and TNFRII in patients with coronary artery disease
    Hajilooi, M
    Sanati, A
    Ahmadieh, A
    Ghofraniha, A
    Massoud, A
    IMMUNOLOGICAL INVESTIGATIONS, 2004, 33 (03) : 263 - 275
  • [3] Circulating ICAM-1, VCAM-1, E-selectin, P-selectin, and TNFαRII in patients with coronary artery disease
    Hajilooi, M
    Sanati, A
    Ahmadieh, A
    Ghofraniha, A
    Massoud, A
    IMMUNOLOGICAL INVESTIGATIONS, 2003, 32 (04) : 245 - 257
  • [4] Influence of single LDL apheresis on the adhesion molecules ICAM, VCAM-1, and P-selectin
    Moll, D
    Mellwig, KP
    Schmidt, HK
    Brinkman, T
    Kleesiek, K
    Horstkotte, D
    EUROPEAN HEART JOURNAL, 2000, 21 : 153 - 153
  • [5] P-selectin binding promotes the adhesion of monocytes to VCAM-1 under flow conditions
    Yago, T
    Tsukuda, M
    Minami, M
    JOURNAL OF IMMUNOLOGY, 1999, 163 (01): : 367 - 373
  • [6] The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study
    Siddiqui, Khalid
    George, Teena P. P.
    Mujammami, Muhammad
    Isnani, Arthur
    Alfadda, Assim A. A.
    FRONTIERS IN ENDOCRINOLOGY, 2023, 14
  • [7] Expression of P-selectin, VCAM-1, and PSGL-1 in traumatic deep venous thrombosis
    Mo, Jianwen
    Zhang, Daifen
    Yang, Renze
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (03): : 3403 - 3409
  • [8] Up-regulation of P-selectin and VCAM-1 is blunted by vitamin E in vivo.
    Desideri, G
    Fabiani, D
    Tomassoni, G
    Croce, G
    Gentile, M
    De Blasis, E
    Masci, P
    Ferri, C
    Santucci, A
    JOURNAL OF HYPERTENSION, 2000, 18 : S222 - S222
  • [9] Expression of VCAM-1, ICAM-1, E-selectin, and P-selectin on endothelium in situ in patients with erythroderma, mycosis fungoides and atopic dermatitis
    Sigurdsson, V
    de Vries, IJM
    Toonstra, J
    Bihari, IC
    Thepen, T
    Bruijnzeel-Koomen, CAFM
    van Vloten, WA
    JOURNAL OF CUTANEOUS PATHOLOGY, 2000, 27 (09) : 436 - 440
  • [10] Leukocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit role of P-selectin, ICAM-1 and VCAM-1
    Scalia, R
    Appel, JZ
    Lefer, AM
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (07) : 1093 - 1100
12345