IL-18, VCAM-1 and P-selectin as early biomarkers in normoalbuminuric Type 2 diabetes patients

被引：21
作者：
Al-Rubeaan, Khalid [1 ]
Nawaz, Shaik S. [2 ]
Youssef, Amira M. [3 ]
Al Ghonaim, Mohammed [4 ]
Siddiqui, Khalid [2 ]
机构：
[1] King Saud Univ, Univ Diabet Ctr, Dept Med, Coll Med, Riyadh, Saudi Arabia
[2] King Saud Univ, Biochem Dept, Strateg Ctr Diabet Res, Riyadh, Saudi Arabia
[3] King Saud Univ, Univ Diabet Ctr, Biochem Dept, Registry Dept, Riyadh, Saudi Arabia
[4] King Saud Univ, King Khalid Universe Hosp, Coll Med, Riyadh, Saudi Arabia
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 06期
关键词：
diabetic kidney disease; diabetic retinopathy; IL-18; low eGFR; pathophysiological role; P-selectin; SAUDI-DKD; Type; 2; diabetes; VCAM-1; YKL-40; CHRONIC KIDNEY-DISEASE; INFLAMMATORY CYTOKINES; DYSFUNCTION; IMPAIRMENT; EXPRESSION; MOLECULES;
D O I：
10.2217/bmm-2018-0359
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To investigate the pathophysiological role of different biomarkers in diabetic kidney disease (DKD) among normoalbuminuric patients with a low-estimated glomerular filtration rate (eGFR). Methods: In this cross-sectional study of 200 normoalbuminuric Type 2 diabetes patients, 28 patients (14%) had a low eGFR. Results: The IL-18, VCAM-1 and P-selectin levels were significantly higher at a low eGFR. On analyzing the area under the receiver operating characteristic curve, these biomarkers had significant diagnostic value and have important pathophysiological role in the progression of DKD. Conclusion: Among normoalbuminuric Type 2 diabetes patients, IL-18, VCAM-1 and P-selectinmay play a significant role in the prediction of early DKD. Further prospective studies need to be conducted to confirm this observation.
引用
收藏
页码：467 / 478
页数：12
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