Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

被引：50
|
作者：
Wan, Long [1 ,2 ,3 ]
Jiao, Jian [1 ]
Cui, Yu [1 ]
Guo, Jingwen [4 ]
Han, Ning [1 ]
Di, Donghua [1 ]
Chang, Di [1 ]
Wang, Pu [4 ]
Jiang, Tongying [1 ]
Wang, Siling [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Pharm, Nanajingbei St 155, Shenyang 110001, Peoples R China
[3] China Med Univ, Coll Pharmaceut Sci, Puhe Rd 77, Shenyang 110122, Peoples R China
[4] Northeastern Univ, Coll Life Sci & Hlth, Wenhuadong Rd 89, Shenyang 110015, Peoples R China
来源：
NANOTECHNOLOGY | 2016年 / 27卷 / 13期
基金：
中国国家自然科学基金;
关键词：
mesoporous carbon nanoparticles; hyaluronic acid; controlled release; co-delivery; SURFACE FUNCTIONALIZATION; ENDOCYTOSIS; NANOTUBES;
D O I：
10.1088/0957-4484/27/13/135102
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this paper, hyaluronic acid (HA) functionalized uniform mesoporous carbon spheres (UMCS) were synthesized for targeted enzyme responsive drug delivery using a facile electrostatic attraction. strategy. This HA. modification ensured. stable drug encapsulation in mesoporous carbon nanoparticles in an. extracellular environment while increasing. colloidal stability, biocompatibility, cell-targeting ability, and controlled cargo release. The cellular uptake experiments of fluorescently. labeled mesoporous carbon nanoparticles, with or without HA functionalization, demonstrated that HA-UMCS are able to specifically target cancer cells overexpressing CD44 receptors. Moreover, the. cargo. loaded. doxorubicin (DOX) and verapamil (VER) exhibited. a dual pH and hyaluronidase-1 responsive release in the tumor microenvironment. In addition,. VER/DOX/HA-UMCS exhibited a superior therapeutic effect on an. in vivo HCT-116 tumor in BALB/c nude mice. In summary, it is expected that HA-UMCS will offer a new method. for targeted co-delivery of drugs to tumors overexpressing CD44 receptors.
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页数：11
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