Vagus nerve modulation of inflammation: Cardiovascular implications

被引：37

作者：

Olshansky, Brian ^{[1
]}

机构：

[1] Univ Iowa Hosp, Cardiac Electrophysiol, Iowa City, IA USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2016年 / 26卷 / 01期

关键词：

CHOLINERGIC ANTIINFLAMMATORY PATHWAY; CHRONIC HEART-FAILURE; TUMOR-NECROSIS-FACTOR; NICOTINIC ACETYLCHOLINE-RECEPTOR; LEFT-VENTRICULAR FUNCTION; C-REACTIVE PROTEIN; VAGAL-STIMULATION; DILATED CARDIOMYOPATHY; CYTOKINE LEVELS; FACTOR-ALPHA;

D O I：

10.1016/j.tcm.2015.03.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The vagus nerve modulates inflammatory responses in various organ systems. Emerging evidence indicates that the vagus can have profound and complex effects on cardiovascular function, remodeling, arrhythmias, and mortality by several mechanisms. In heart failure and during ischemia, an adverse inflammatory response can occur. The vagus nerve may modulate cardiovascular disease and outcomes by affecting inflammatory responses. Here, evidence for and components of the vagus inflammatory reflex are reviewed and evidence for and implications of effects of vagus activation on inflammation in the cardiovascular system are considered. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：1 / 11

页数：11

共 105 条

[1] The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells [J].

Alvarez-Guardia, David ;

Palomer, Xavier ;

Coll, Teresa ;

Davidson, Mercy M. ;

Chan, Tung O. ;

Feldman, Arthur M. ;

Laguna, Juan C. ;

Vazquez-Carrera, Manuel .

CARDIOVASCULAR RESEARCH, 2010, 87 (03) :449-458

[2] How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH [J].

Anker, SD ;

Coats, AJS .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 86 (2-3) :123-130

[3] Inflammatory and anti-inflammatory cytokines in chronic heart failure:: Potential therapeutic implications [J].

Aukrust, P ;

Gullestad, L ;

Ueland, T ;

Damås, JK ;

Yndestad, A .

ANNALS OF MEDICINE, 2005, 37 (02) :74-85

[4] Elevated circulating levels of C-C chemokines in patients with congestive heart failure [J].

Aukrust, P ;

Ueland, T ;

Müller, F ;

Andreassen, AK ;

Nordoy, I ;

Aas, H ;

Kjekshus, J ;

Simonsen, S ;

Froland, SS ;

Gullestad, L .

CIRCULATION, 1998, 97 (12) :1136-1143

[5] Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy [J].

Aukrust, P ;

Ueland, T ;

Lien, E ;

Bendtzen, K ;

Müller, F ;

Andreassen, AK ;

Nordoy, I ;

Aass, H ;

Espevik, T ;

Simonsen, S ;

Froland, SS ;

Gullestad, L .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (03) :376-382

[6] Parasympathetic control of cardiac sympathetic activity - Normal ventricular function versus congestive heart failure [J].

Azevedo, ER ;

Parker, JD .

CIRCULATION, 1999, 100 (03) :274-279

[7] Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion [J].

Bernik, TR ;

Friedman, SG ;

Ochani, M ;

DiRaimo, R ;

Susarla, S ;

Czura, CJ ;

Tracey, KJ .

JOURNAL OF VASCULAR SURGERY, 2002, 36 (06) :1231-1235

[8] Pharmacological stimulation of the cholinergic antiinflammatory pathway [J].

Bernik, TR ;

Friedman, SG ;

Ochani, M ;

DiRaimo, R ;

Ulloa, L ;

Yang, H ;

Sudan, S ;

Czura, CJ ;

Ivanova, SM ;

Tracey, KJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (06) :781-788

[9] Role of Pre-procedural C-reactive Protein Level in the Prediction of Major Adverse Cardiac Events in Patients Undergoing Percutaneous Coronary Intervention: a Meta-analysisof Longitudinal Studies [J].

Bibek, Singh-baniya ;

Xie, Yong ;

Gao, Jia-jia ;

Wang, Zhi ;

Wang, Jing-feng ;

Geng, Deng-feng .

INFLAMMATION, 2015, 38 (01) :159-169

[10] Evidence for impaired vagus nerve activity in heart failure [J].

Bibevski, Steve ;

Dunlap, Mark E. .

HEART FAILURE REVIEWS, 2011, 16 (02) :129-135

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