RIFM fragrance ingredient safety assessment, ethyl methacrylate, CAS Registry Number 97-63-2

被引：0

作者：

Api, A. M. ^{[1
]}

Belsito, D. ^{[2
]}

Botelho, D. ^{[1
]}

Bruze, M. ^{[3
]}

Burton, G. A., Jr. ^{[4
]}

Dagli, M. L. ^{[6
]}

Dekant, W. ^{[7
]}

Deodhar, C. ^{[1
]}

Fryer, A. D. ^{[8
]}

Jones, L. ^{[1
]}

Joshi, K. ^{[1
]}

Lapczynski, A. ^{[1
]}

Liebler, D. C. ^{[9
]}

Sullivan, G. ^{[1
]}

Thakkar, Y. ^{[1
]}

Tokura, Y. ^{[13
]}

Francis, M. ^{[1
]}

La Cava, S. ^{[1
]}

O'Brien, D. ^{[1
]}

Patel, A. ^{[1
]}

Penningi, T. M. ^{[10
]}

Ritacco, G. ^{[1
]}

Romine, J. ^{[1
]}

Sadekar, N. ^{[1
]}

Salvito, D. ^{[1
]}

Schultz, T. W. ^{[11
]}

Sipes, I. G. ^{[12
]}

Buschmann, J. ^{[5
]}

Date, M. ^{[1
]}

机构：

[1] Res Inst Fragrance Mat Inc, 50 Tice Blvd, Woodcliff Lake, NJ 07677 USA

[2] Columbia Univ, Dept Dermatol, Med Ctr, Member RIFM Expert Panel, 161 Ft Washington Ave, New York, NY 10032 USA

[3] Malmo Univ Hosp, Dept Occupat & Environm Dermatol, Member RIFM Expert Panel, Sodra Forstadsgatan 101,Entrance 47, SE-20502 Malmo, Sweden

[4] Univ Michigan, Sch Nat Resources & Environm, Member RIFM Expert Panel, Dana Bldg G110,440 Church St, Ann Arbor, MI 58109 USA

[5] Fraunhofer Inst Toxicol & Expt Med, Member RIFM Expert Panel, Nikolai Fuchs Str 1, D-30625 Hannover, Germany

[6] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Member RIFM Expert Panel, Av Prof Dr Orlando Marques Paiva 87, BR-05508900 Sao Paulo, Brazil

[7] Univ Wurzburg, Dept Toxicol, Member RIFM Expert Panel, Versbacher Str 9, D-97078 Wurzburg, Germany

[8] Oregon Hlth & Sci Univ, Member RIFM Expert Panel, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[9] Vanderbilt Univ, Ctr Mol Toxicol, Dept Biochem, Member RIFM Expert Panel,Sch Med, 638 Robinson Res Bldg,2200 Pierce Ave, Nashville, TN 37232 USA

[10] Univ Penn, Ctr Excellence Environm Toxicol, Perelman Sch Med, Member RIFM Expert Panel, 1316 Biomed Res Bldg BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA

[11] Univ Tennessee, Coll Vet Med, Dept Comparat Med, Member RIFM Expert Panel, 2407 River Dr, Knoxville, TN 37996 USA

[12] Univ Arizona, Coll Med, Dept Pharmacol, Member RIFM Expert Panel, 1501 North Campbell Ave,POB 245050, Tucson, AZ 85724 USA

[13] Hamamatsu Univ Sch Med, Dept Dermatol, Member RIFM Expert Panel, Journal Dermatol Sci JDS,Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 146卷

关键词：

RAT NASAL EPITHELIUM; METHYL-METHACRYLATE; PERSONAL CARE; DEVELOPMENTAL TOXICITY; INHALATION TOXICITY; CONSUMER EXPOSURE; THRESHOLD; MODEL; ABSORPTION; COSMETICS;

D O I：

10.1016/j.fct.2020.111779

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The existing information supports the use of this material as described in this safety assessment. Ethyl methacrylate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that ethyl methacrylate is not genotoxic. Data on read-across analog butyl methacrylate (CAS # 97-88-1) provide a calculated margin of exposure (MOE) > 100 for the repeated dose toxicity and fertility endpoints. Data on ethyl methacrylate provide a calculated MOE >100 for the developmental toxicity endpoint. The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for reactive materials (64 mu g/cm(2)); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; ethyl methacrylate is not expected to be phototoxic/photoallergenic. For the local respiratory endpoint, a calculated MOE >100 was provided by the read-across analog methyl methacrylate (CAS # 80-62-6). The environmental endpoints were evaluated; ethyl methacrylate is not persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, ethyl methacrylate was not able to be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.

引用

页数：11

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