Tipping the balance toward longevity

被引：11

作者：

Antebi, A ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1534-5807(04)00068-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.

引用

收藏

页码：315 / 316

页数：2

相关论文

共 10 条

[1]

BRUNET A, 2004, IN PRESS SCIENC 0219

[2] Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice [J].

Cheng, HL ;

Mostoslavsky, R ;

Saito, S ;

Manis, JP ;

Gu, YS ;

Patel, P ;

Bronson, R ;

Appella, E ;

Alt, FW ;

Chua, KF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10794-10799

[3] Genetics and the specificity of the aging process [J].

Hekimi, S ;

Guarente, L .

SCIENCE, 2003, 299 (5611) :1351-1354

[4] Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan [J].

Howitz, KT ;

Bitterman, KJ ;

Cohen, HY ;

Lamming, DW ;

Lavu, S ;

Wood, JG ;

Zipkin, RE ;

Chung, P ;

Kisielewski, A ;

Zhang, LL ;

Scherer, B ;

Sinclair, DA .

NATURE, 2003, 425 (6954) :191-196

[5] Negative control of p53 by Sir2α promotes cell survival under stress [J].

Luo, JY ;

Nikolaev, AY ;

Imai, S ;

Chen, DL ;

Su, F ;

Shiloh, A ;

Guarente, L ;

Gu, W .

CELL, 2001, 107 (02) :137-148

[6] Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway [J].

Miyauchi, H ;

Minamino, T ;

Tateno, K ;

Kunieda, T ;

Toko, H ;

Komuro, I .

EMBO JOURNAL, 2004, 23 (01) :212-220

[7] Mammalian SIRT1 represses forkhead transcription factors [J].

Motta, MC ;

Divecha, N ;

Lemieux, M ;

Kamel, C ;

Chen, D ;

Gu, W ;

Bultsma, Y ;

McBurney, M ;

Guarente, L .

CELL, 2004, 116 (04) :551-563

[8] The endocrine regulation of aging by insulin-like signals [J].

Tatar, M ;

Bartke, A ;

Antebi, A .

SCIENCE, 2003, 299 (5611) :1346-1351

[9] Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans [J].

Tissenbaum, HA ;

Guarente, L .

NATURE, 2001, 410 (6825) :227-230

[10] p53 mutant mice that display early ageing-associated phenotypes [J].

Tyner, SD ;

Venkatachalam, S ;

Choi, J ;

Jones, S ;

Ghebranious, N ;

Igelmann, H ;

Lu, XB ;

Soron, G ;

Cooper, B ;

Brayton, C ;

Park, SH ;

Thompson, T ;

Karsenty, G ;

Bradley, A ;

Donehower, LA .

NATURE, 2002, 415 (6867) :45-53