G2S: a web-service for annotating genomic variants on 3D protein structures

被引：11

作者：

Wang, Juexin ^{[1
,2
]}

Sheridan, Robert ^{[3
]}

Sumer, S. Onur ^{[3
]}

Schultz, Nikolaus ^{[3
,4
]}

Xu, Dong ^{[1
,2
]}

Gao, Jianjiong ^{[3
]}

机构：

[1] Univ Missouri, Dept Elect Engn & Comp Sci, Columbia, MO 65211 USA

[2] Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA

[3] Mem Sloan Kettering Canc Ctr, Kravis Ctr Mol Oncol, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol Biostat, New York, NY 10065 USA

来源：

BIOINFORMATICS | 2018年 / 34卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/bioinformatics/bty047

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Accurately mapping and annotating genomic locations on 3D protein structures is a key step in structure-based analysis of genomic variants detected by recent large-scale sequencing efforts. There are several mapping resources currently available, but none of them provides a web API (Application Programming Interface) that supports programmatic access. Results: We present G2S, a real-time web API that provides automated mapping of genomic variants on 3D protein structures. G2S can align genomic locations of variants, protein locations, or protein sequences to protein structures and retrieve the mapped residues from structures. G2S API uses REST-inspired design and it can be used by various clients such as web browsers, command terminals, programming languages and other bioinformatics tools for bringing 3D structures into genomic variant analysis.

引用

页码：1949 / 1950

页数：2

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