Visible light-induced radical cascade reaction of acryloylbenzamides with N-hydroxyphthalimide esters

被引：9
|
作者：
Cai, Xingxing [1 ]
Liu, Yihuo [1 ]
Ding, Siyu [1 ]
Fu, Jiahui [1 ]
Li, Jinghua [2 ]
Cheng, Dongping [2 ]
Xu, Xiaoliang [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
TETRAHEDRON LETTERS | 2022年 / 95卷
基金：
中国国家自然科学基金;
关键词：
Isoquinolinediones; Acryloylbenzamides; Cyclization reaction; Visible light; Photocatalysis; SELECTIVE INHIBITORS; METHACRYLOYL BENZAMIDES; PHOTOREDOX CATALYSIS; ACTIVATED ALKENES; RNASE-H; CYCLIZATION; ADDITION/CYCLIZATION; ALKYLARYLATION; ALKYLATION; DESIGN;
D O I：
10.1016/j.tetlet.2022.153722
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and mild cascade reaction of acryloylbenzamides with N-hydroxyphthalimide (NHPI) esters is disclosed. It goes through radical addition and subsequent cyclization to give 4-alkylated isoquinolinediones in the presence of visible light and photocatalyst Ir[dF(CF3)ppy(2)](dtbbpy)PF6.(C) 2022 Elsevier Ltd. All rights reserved.
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页数：4
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