Withanolides from Physalis minima and their inhibitory effects on nitric oxide production

被引：45

作者：

Guan, Yu-Zhou ^{[1
]}

Shan, Si-Ming ^{[1
]}

Zhang, Wei ^{[1
]}

Luo, Jian-Guang ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

STEROIDS | 2014年 / 82卷

关键词：

Physalis minima; Withanolides; Physaminimins A-F; Nitric oxide; CYTOTOXIC WITHAPHYSALINS; WITHANIA-SOMNIFERA; STEROIDS; CONSTITUENTS; PLANTS;

D O I：

10.1016/j.steroids.2014.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new withanolides (1-6), including two uncommon 1,10-seco withanolides (1 and 2), together with five known withanolides (7-11), were isolated from the whole plants of Physalis minima Linn.. The structures of new compounds were elucidated through spectroscopic methods, including H-1, C-13 NMR, 2D-NMR, HRESIMS and circular dichroism (CD). Inhibitory effects of the isolates on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated. Compounds 2 and 5 showed strong inhibitory activities with IC50 values of 8.04 and 10.01 mu M, respectively. Compounds 1, 9 and 10 exhibited moderate inhibitory activities with IC50 values from 25.54 to 43.58 mu M. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：38 / 43

页数：6

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