Mitoepigenetics: The different shades of grey

被引：29

作者：

Ghosh, Sourav ^{[1
]}

Singh, Keshav K. ^{[2
,3
,4
,5
]}

Sengupta, Shantanu ^{[1
,7
]}

Scaria, Vinod ^{[6
,7
]}

机构：

[1] CSIR Inst Genom & Integrat Biol, Genom & Mol Med, Delhi 110020, India

[2] Univ Alabama Birmingham, Dept Genet, Pathol, Environm Hlth, Birmingham, AL USA

[3] Univ Alabama Birmingham, Ctr Aging, Ctr Free Rad Biol, Birmingham, AL USA

[4] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL USA

[5] Birmingham Vet Affairs Med Ctr, Birmingham, AL 35294 USA

[6] CSIR Inst Genom & Integrat Biol, GN Ramachandran Knowledge Ctr Genome Informat, Delhi 110020, India

[7] Acad Sci & Innovat Res AcSIR, Delhi 110020, India

来源：

MITOCHONDRION | 2015年 / 25卷

关键词：

Mitochondria; Epigenetics; Methylation; Mitochondrial DNA methylation; Mitoepigenetics; MITOCHONDRIAL-DNA MUTATIONS; DEOXYRIBONUCLEIC-ACID; EPIGENETIC REGULATION; CPG METHYLATION; GENOME; HYDROXYMETHYLATION; CYTOSINE; PATTERN; ABSENCE; GENES;

D O I：

10.1016/j.mito.2015.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic modifications of the nuclear genome have been well studied and it is established that these modifications play a key role in nuclear gene expression. However, the status of mitochondrial epigenetic modifications has not been delved in detail. The recent technological advancements in the genome analyzing tools and techniques, have helped in investigating mitochondrial epigenetic modifications with greater resolution and studies have indicated a regulatory role of the mitochondrial epigenome. Association of mitochondrial DNA methylation with various disease conditions, drug treatment, aging, exposure to environmental pollutants etc. has lent credence to this belief. Herein, we have reviewed studies on mitochondrial epigenetic modifications with a focus to comprehend its regulatory role in gene expression and disease association. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：60 / 66

页数：7

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