Unmasking molecular profiles of bladder cancer

被引：25
作者：
Piao, Xuan-Mei [1 ]
Byun, Young Joon [1 ]
Kim, Wun-Jae [1 ]
Kim, Jayoung [2 ,3 ,4 ]
机构：
[1] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, South Korea
[2] Cedars Sinai Med Ctr, Dept Surg, 8700 Beverly Blvd,Davis Res Bldg 5071, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Dept Biomed Sci, 8700 Beverly Blvd,Davis Res Bldg 5071, Los Angeles, CA 90048 USA
[4] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
来源：
INVESTIGATIVE AND CLINICAL UROLOGY | 2018年 / 59卷 / 02期
关键词：
Biomarkers; Liquid biopsy; Precision medicine; Urinary bladder neoplasms; TRANSITIONAL-CELL CARCINOMA; CIRCULATING TUMOR-CELLS; IN-SITU-HYBRIDIZATION; UROTHELIAL CARCINOMA; URINE SEDIMENTS; EMERGING ROLE; BIOMARKERS; MUTATIONS; MARKERS; METHYLATION;
D O I：
10.4111/icu.2018.59.2.72
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc. The aim of this short review is to outline the current technologies being used to investigate molecular profiles and discuss biomarker candidates that have been investigated as possible diagnostic and prognostic indicators of bladder cancer.
引用
收藏
页码：72 / 82
页数：11
相关论文
共 100 条
  • [31] Gomella LG, 2017, CAN J UROL, V24, P8620
  • [32] TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence:: A prospective study
    Gormally, Emmanuelle
    Vineis, Paolo
    Matullo, Giuseppe
    Veglia, Fabrizio
    Caboux, Elodie
    Le Roux, Emilie
    Peluso, Marco
    Garte, Seymour
    Guarrera, Simonetta
    Munnia, Armelle
    Airoldi, Luisa
    Autrup, Herman
    Malaveille, Christian
    Dunning, Alison
    Overvad, Kim
    Tjonneland, Anne
    Lund, Eiliv
    Clavel-Chapelon, Francoise
    Boeing, Heiner
    Trichopoulou, Antonia
    Palli, Domenico
    Krogh, Vittorio
    Tumino, Rosario
    Panico, Salvatore
    Bueno-de-Mesquita, H. Bas
    Peeters, Petra H.
    Pera, Guillem
    Martinez, Carmen
    Dorronsoro, Miren
    Barricarte, Aurelio
    Navarro, Carmen
    Quiros, Jose Ramon
    Hallmans, Goran
    Day, Nicholas E.
    Key, Timothy J.
    Saracci, Rodolfo
    Kaaks, Rudolf
    Riboli, Elio
    Hainaut, Pierre
    [J]. CANCER RESEARCH, 2006, 66 (13) : 6871 - 6876
  • [33] A Quantitative Proteomic Analysis Uncovers the Relevance of CUL3 in Bladder Cancer Aggressiveness
    Grau, Laura
    Luque-Garcia, Jose L.
    Gonzalez-Peramato, Pilar
    Theodorescu, Dan
    Palou, Joan
    Fernandez-Gomez, Jesus M.
    Sanchez-Carbayo, Marta
    [J]. PLOS ONE, 2013, 8 (01):
  • [34] Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    Gui, Yaoting
    Guo, Guangwu
    Huang, Yi
    Hu, Xueda
    Tang, Aifa
    Gao, Shengjie
    Wu, Renhua
    Chen, Chao
    Li, Xianxin
    Zhou, Liang
    He, Minghui
    Li, Zesong
    Sun, Xiaojuan
    Jia, Wenlong
    Chen, Jinnong
    Yang, Shangming
    Zhou, Fangjian
    Zhao, Xiaokun
    Wan, Shengqing
    Ye, Rui
    Liang, Chaozhao
    Liu, Zhisheng
    Huang, Peide
    Liu, Chunxiao
    Jiang, Hui
    Wang, Yong
    Zheng, Hancheng
    Sun, Liang
    Liu, Xingwang
    Jiang, Zhimao
    Feng, Dafei
    Chen, Jing
    Wu, Song
    Zou, Jing
    Zhang, Zhongfu
    Yang, Ruilin
    Zhao, Jun
    Xu, Congjie
    Yin, Weihua
    Guan, Zhichen
    Ye, Jiongxian
    Zhang, Hong
    Li, Jingxiang
    Kristiansen, Karsten
    Nickerson, Michael L.
    Theodorescu, Dan
    Li, Yingrui
    Zhang, Xiuqing
    Li, Songgang
    Wang, Jian
    [J]. NATURE GENETICS, 2011, 43 (09) : 875 - 878
  • [35] Engineered 3D environments to elucidate the effect of environmental parameters on drug response in cancer
    Hakanson, Maria
    Textor, Marcus
    Charnley, Mirren
    [J]. INTEGRATIVE BIOLOGY, 2011, 3 (01) : 31 - 38
  • [36] Fluorescence-in-situ-hybridization in the Surveillance of Urothelial Cancers: Can Use of Cystoscopy or Ureteroscopy be Deferred?
    Ho, Christopher Chee Kong
    Tan, Wei Phin
    Pathmanathan, Rajadurai
    Tan, Wei Keith
    Tan, Hui Meng
    [J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (07) : 4057 - 4059
  • [37] Translating the histone code
    Jenuwein, T
    Allis, CD
    [J]. SCIENCE, 2001, 293 (5532) : 1074 - 1080
  • [38] Diagnosis of bladder cancer and prediction of survival by urinary metabolomics
    Jin, Xing
    Yun, Seok Joong
    Jeong, Pildu
    Kim, Isaac Yi
    Kim, Wun-Jae
    Park, Sunghyouk
    [J]. ONCOTARGET, 2014, 5 (06) : 1635 - 1645
  • [39] Surgical Advances in Bladder Cancer At What Cost?
    Johnson, David C.
    Greene, Peter S.
    Nielsen, Matthew E.
    [J]. UROLOGIC CLINICS OF NORTH AMERICA, 2015, 42 (02) : 235 - +
  • [40] Bladder cancer
    Kaufman, Donald S.
    Shipley, William U.
    Feldman, Adam S.
    [J]. LANCET, 2009, 374 (9685) : 239 - 249
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