Unmasking molecular profiles of bladder cancer

被引：25
作者：
Piao, Xuan-Mei [1 ]
Byun, Young Joon [1 ]
Kim, Wun-Jae [1 ]
Kim, Jayoung [2 ,3 ,4 ]
机构：
[1] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, South Korea
[2] Cedars Sinai Med Ctr, Dept Surg, 8700 Beverly Blvd,Davis Res Bldg 5071, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Dept Biomed Sci, 8700 Beverly Blvd,Davis Res Bldg 5071, Los Angeles, CA 90048 USA
[4] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
来源：
INVESTIGATIVE AND CLINICAL UROLOGY | 2018年 / 59卷 / 02期
关键词：
Biomarkers; Liquid biopsy; Precision medicine; Urinary bladder neoplasms; TRANSITIONAL-CELL CARCINOMA; CIRCULATING TUMOR-CELLS; IN-SITU-HYBRIDIZATION; UROTHELIAL CARCINOMA; URINE SEDIMENTS; EMERGING ROLE; BIOMARKERS; MUTATIONS; MARKERS; METHYLATION;
D O I：
10.4111/icu.2018.59.2.72
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc. The aim of this short review is to outline the current technologies being used to investigate molecular profiles and discuss biomarker candidates that have been investigated as possible diagnostic and prognostic indicators of bladder cancer.
引用
收藏
页码：72 / 82
页数：11
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