Middle East respiratory syndrome: pathogenesis and therapeutic developments

被引：27

作者：

Choudhry, Hani ^{[1
]}

Bakhrebah, Muhammed A. ^{[2
]}

Abdulaal, Wesam H. ^{[1
]}

Zamzami, Mazin A. ^{[1
]}

Baothman, Othman A. ^{[1
]}

Hassan, Mohammed A. ^{[1
,3
]}

Zeyadi, Mustafa ^{[1
]}

Helmi, Nawal ^{[1
]}

Alzahrani, Faisal A. ^{[10
,11
]}

Ali, Ashraf ^{[4
,5
,6
]}

Zakaria, Mohammad K. ^{[7
]}

Kamal, Mohammad A. ^{[8
]}

Warsi, Mohiuddin K. ^{[7
]}

Ahmed, Firoz ^{[7
]}

Rasool, Mahmood ^{[9
]}

Jamal, Mohammad S. ^{[3
,4
]}

机构：

[1] King Abdulaziz Univ, King Fahd Med Res Ctr, Canc Metab & Epigenet Unit, Canc & Mutagenesis Unit,Dept Biochem,Fac Sci, Jeddah 21589, Saudi Arabia

[2] KACST, Natl Ctr Genome Technol, Life Sci & Environm Res Inst, Riyadh 12371, Saudi Arabia

[3] Hadhramout Univ, Coll Med & Hlth Sci, Dept Basic Med Sci, Al Mukalla, Yemen

[4] King Abdulaziz Univ, King Fahd Med Res Ctr, Hematol Lab Unit, Jeddah 21589, Saudi Arabia

[5] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah 21589, Saudi Arabia

[6] Univ Foggia, Dept Sci Agr Food & Environm SAFE, Via Napoli 25, I-71122 Foggia, Italy

[7] Pirbright Inst, Ash Rd, Surrey GU240NF, England

[8] Univ Jeddah, Dept Biochem, Jeddah 23890, Saudi Arabia

[9] King Abdulaziz Univ, Ctr Excellence Genom MedicineRes, Jeddah 21589, Saudi Arabia

[10] King Abdulaziz Univ, King Fahd MedicalRes Ctr, Fac Sci, Dept Biochem,Stem Cells Unit, Jeddah 21589, Saudi Arabia

[11] Aston Univ, Aston Med Sch, AstonMed Res Inst, Birmingham B4 7ET, W Midlands, England

来源：

FUTURE VIROLOGY | 2019年 / 14卷 / 04期

关键词：

Arabian Peninsula; coronavirus; global; macrophages; MERS; SARS; Saudi Arabia; therapeutic; vaccine; WHO; CORONAVIRUS MERS-COV; RECEPTOR-BINDING DOMAIN; DIPEPTIDYL PEPTIDASE 4; MOUSE MODEL; MONOCLONAL-ANTIBODY; CLINICAL-FEATURES; SPIKE PROTEIN; INFECTION; SARS; REPLICATION;

D O I：

10.2217/fvl-2018-0201

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.

引用

页码：237 / 246

页数：10

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