Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells

被引：4

作者：

Albegova, D. Z. ^{[1
]}

Kamkina, O. V. ^{[1
]}

Pavlova, S. I. ^{[3
]}

Albegova, Zh. K. ^{[4
]}

Laptev, O. S. ^{[2
]}

Kozlov, I. G. ^{[1
,2
]}

机构：

[1] NI Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Dept Pharmacol, Moscow, Russia

[2] D Rogachev Fed Res & Clin Ctr Pediat Hematol Onco, Moscow, Russia

[3] IN Ulyanov Chuvash State Univ, Cheboksary, Russia

[4] North Ossetian State Med Acad, Minist Hlth Russian Federat, Vladikavkaz, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 05期

关键词：

flavonoids; cytokines; mononuclear cells;

D O I：

10.1007/s10517-015-3031-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-gamma and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4(+) T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content. The content of IL-17 was shown to decrease above the detection limit.

引用

页码：626 / 628

页数：3

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