Somatostatin analogues and exocrine pancreatic secretion

被引:5
|
作者
Gullo, L
机构
[1] Department of Medicine and Gastroenterology, University of Bologna, St. Orsola Hospital, Bologna
关键词
somatostatin; octreotide; exocrine; pancreas secretion; fistula; acinar cells; enzyme;
D O I
10.1159/000201408
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Subcutaneous injection of 50 mu g octreotide before a meal can almost totally prevent the increase in exocrine:pancreatic secretions caused by the meal. Octreotide inhibits plasma amino acid uptake by pancreatic acinar cells, and thus synthesis of pancreatic enzymes, This effect has clinical potential.
引用
收藏
页码:93 / 93
页数:1
相关论文
共 50 条
  • [21] Octreotide inhibits pancreatic exocrine secretion and prevents pancreatoenterostomy leakage
    Nakatsuka, A
    Yamaguchi, K
    Chijiiwa, K
    Tanaka, M
    INTERNATIONAL SURGERY, 2000, 85 (02) : 124 - 129
  • [22] Therapeutic applications of somatostatin analogues
    Osapay, G
    Osapay, K
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (07) : 855 - 870
  • [23] Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion
    Phillips, Phoebe A.
    Yang, Lu
    Shulkes, Arthur
    Vonlaufen, Alain
    Poljak, Anne
    Bustamante, Sonia
    Warren, Alessandra
    Xu, Zhihong
    Guilhaus, Michael
    Pirola, Romano
    Apte, Minoti V.
    Wilson, Jeremy S.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (40) : 17397 - 17402
  • [24] EFFECT OF CYSTEAMINE ON INSULIN RELEASE AND EXOCRINE PANCREATIC-SECRETION INVITRO
    VONSCHONFELD, J
    MULLER, MK
    AUGUSTIN, M
    RUNZI, M
    GOEBELL, H
    DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (01) : 28 - 32
  • [25] Somatostatin analogues for somatostatin-receptor-mediated radiotherapy of cancer
    Stoltz, B
    SmithJones, P
    Albert, R
    Tolcsvai, L
    Briner, U
    Ruser, G
    Macke, H
    Weckbecker, G
    Bruns, C
    DIGESTION, 1996, 57 : 17 - 21
  • [26] MECHANISM OF ACTION OF INSULIN ON PANCREATIC EXOCRINE SECRETION IN PERFUSED RAT PANCREAS
    LEE, KY
    LEE, YL
    KIM, CD
    CHANG, TM
    CHEY, WY
    AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (02): : G207 - G212
  • [27] EFFECT OF ENDOGENOUS INSULIN ON PANCREATIC EXOCRINE SECRETION IN PERFUSED DOG PANCREAS
    LEE, KY
    KRUSCH, D
    ZHOU, L
    SONG, Y
    CHANG, TM
    CHEY, WY
    PANCREAS, 1995, 11 (02) : 190 - 195
  • [28] Changes in exocrine and endocrine secretion of the pancreas in the treatment of chronic pancreatitis of alcoholic etiology with somatostatin analogue
    Vinokurova, LV
    Astafyeva, OV
    Banifatov, PV
    TERAPEVTICHESKII ARKHIV, 2003, 75 (02) : 48 - 50
  • [29] Somatostatin-receptor 2 (sst2)-mediated effects of endogenous somatostatin on exocrine and endocrine secretion of the rat stomach
    Fykse, V
    Coy, DH
    Waldum, HL
    Sandvik, AK
    BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (03) : 416 - 421
  • [30] When and How to Use Somatostatin Analogues
    de Herder, Wouter W.
    ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2018, 47 (03) : 549 - +