SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma

被引：23

作者：

Sethi, Gautam ^{[1
,2
,3
]}

Shanmugam, Muthu K. ^{[3
]}

Kumar, Alan Prem ^{[3
,4
,5
,6
]}

机构：

[1] Ton Duc Thang Univ, Dept Management Sci & Technol Dev, Ho Chi Minh City, Vietnam

[2] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

[4] Natl Univ Singaporee, Canc Sci Inst Singapore, Singapore, Singapore

[5] Natl Univ Singaporea, Yong Loo Lin Sch Med, Med Sci Cluster, Singapore, Singapore

[6] Natl Univ Hlth Syst, Natl Univ Canc Inst, Singapore, Singapore

来源：

BIOSCIENCE REPORTS | 2017年 / 37卷

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

LIPID-METABOLISM; CANCER METABOLISM; KIDNEY CANCER; PROLIFERATION; INFLAMMATION; PHYSIOLOGY; TARGET; RNF20; GENE;

D O I：

10.1042/BSR20171270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii:MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 (PTTG1)-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis.

引用

页数：5

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